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Public LC-Orbitrap-MSMS Spectral Library for Metabolite Identification

Published: Nov. 22, 2020, 12:03 p.m.
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Listed in: Science

Crosstalk between repair pathways elicits Double-Strand Breaks in alkylated DNA: implications for the action of temozolomide

Published: Nov. 22, 2020, 11:02 a.m.
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CM1-driven assembly and activation of Yeast γ-Tubulin Small Complex underlies microtubule nucleation

Published: Nov. 22, 2020, 11:02 a.m.
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A CDK-regulated chromatin segregase promoting chromosome replication

Published: Nov. 22, 2020, 11:02 a.m.
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Dietary zinc restriction induces nociceptive pain with reduced inflammation in mice

Published: Nov. 22, 2020, 3:03 a.m.
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Comparative biochemistry of four polyester (PET) hydrolases

Published: Nov. 21, 2020, 4:01 p.m.
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Extracellular vesicles from human adipose stem cells are neuroprotective after stroke in rats

Published: Nov. 19, 2020, 7:03 p.m.
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Common allotypes of ER aminopeptidase 1 have substrate- dependent and highly variable enzymatic properties

Published: Nov. 19, 2020, 7:03 p.m.
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CHD7 interacts with the nucleosome acidic patch for its efficient activity via its N-terminal region

Published: Nov. 19, 2020, 4:02 p.m.
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Improved production of SARS-CoV-2 spike receptor-binding domain (RBD) for serology assays

Published: Nov. 18, 2020, 9:01 p.m.
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Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc

Published: Nov. 18, 2020, 7:01 p.m.
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Structural basis of ligand selectivity by a bacterial adhesin lectin involved in multi- species biofilm formation

Published: Nov. 18, 2020, 4:02 a.m.
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A unique adhesive motif of protein disulfide isomerase P5 supports its function via dimerization

Published: Nov. 18, 2020, 3:02 a.m.
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Design to Data for mutants of β-glucosidase B from Paenibacillus polymyxa: L171M, H178M, M221L, E406W, N160E, F415M

Published: Nov. 18, 2020, 3:02 a.m.
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Shape and size complementarity induced formation of supramolecular protein assemblies with metal-oxo clusters

Published: Nov. 18, 2020, 3:02 a.m.
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Novel quaternary structures of the human prion protein globular domain

Published: Nov. 17, 2020, 5:02 p.m.
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"Multiplex" rheostat positions cluster around allosterically critical regions of the lactose repressor protein

Published: Nov. 17, 2020, 7:01 a.m.
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The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

Published: Nov. 17, 2020, 6:01 a.m.
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High Spatial-Resolution Imaging Of The Dynamics Of Cuticular Lipid Deposition During Arabidopsis Flower Development

Published: Nov. 17, 2020, 4:02 a.m.
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Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization

Published: Nov. 17, 2020, 3:03 a.m.
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Amphipathic Fluorescent Dyes for Sensitive and Long-Term Monitoring of Plasma Membranes

Published: Nov. 17, 2020, 2:03 a.m.
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Conformational dynamics of -synuclein during the interaction with phospholipid nanodiscs by Millisecond Hydrogen Deuterium Exchange Mass Spectrometry

Published: Nov. 17, 2020, 1:02 a.m.
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Incidence and Risk Factors of Combined-Antiretroviral Therapy-Induced Hepatotoxicity among HIV Patients at the Bali District Hospital, Cameroon.

Published: Nov. 16, 2020, 7:02 a.m.
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Analysis of SARS-CoV-2 spike glycosylation reveals shedding of a vaccine candidate

Published: Nov. 16, 2020, 4:02 a.m.
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A Universal Allosteric Mechanism for G Protein Activation

Published: Nov. 16, 2020, 3:03 a.m.
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Structural Investigation of Oat Protein Isolate in Aqueous Medium by using Synchrotron Small-angle X-ray Scattering

Published: Nov. 15, 2020, 11:03 a.m.
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Can a nick promote partial genome re-replication?

Published: Nov. 15, 2020, 11:03 a.m.
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Structure of the complete dimeric human GDAP1 core domain provides insights into ligand binding and clustering of disease mutations

Published: Nov. 14, 2020, 11:02 a.m.
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Conserved prolines in the coiled coil-OB domain linkers of proteasomal ATPases facilitate eukaryotic proteasome base assembly

Published: Nov. 14, 2020, 10:02 a.m.
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Zika Virus Capsid Anchor Forms Cytotoxic Amyloid-like Fibrils

Published: Nov. 14, 2020, 10:01 a.m.
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Characterization of LC-MS based urine metabolomics in healthy subjects across the life span

Published: Nov. 13, 2020, 12:01 a.m.
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A Recombinant Protein Biomarker DDA Library Increases DIA Coverage of Low Abundance Plasma Proteins

Published: Nov. 12, 2020, 11:02 p.m.
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Oxygen-dependent changes in HIF binding partners and post-translational modifications regulate stability and transcriptional activity

Published: Nov. 12, 2020, 9:04 p.m.
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Bioinformatic and computational analysis reveals the prevalence and nature of PY motif-mediated protein-protein interactions in the Nedd4 family of ubiquitin ligases

Published: Nov. 12, 2020, 3:02 a.m.
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The repurposed drugs suramin and quinacrine inhibit cooperatively in vitro SARS-CoV-2 3CLpro

Published: Nov. 12, 2020, 2:02 a.m.
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Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains

Published: Nov. 11, 2020, 8:03 p.m.
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Structure of the Human Signal Peptidase Complex Reveals the Determinants for Signal Peptide Cleavage

Published: Nov. 11, 2020, 4:02 a.m.
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The structural basis of fatty acid elongation by the ELOVL elongases

Published: Nov. 11, 2020, 4:02 a.m.
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Enzyme catalysis prior to aromatic residues: reverse engineering of a dephosphoCoA kinase

Published: Nov. 11, 2020, 4:02 a.m.
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Multistep mechanism of DNA replication-coupled G-quadruplex resolution

Published: Nov. 11, 2020, 4:02 a.m.
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The role of XPBSsl2 double-stranded DNA translocase processivity in transcription start-site scanning.

Published: Nov. 10, 2020, 3:02 p.m.
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Glucocorticoid receptor condensates link DNA-dependent receptor dimerization and transcriptional transactivation

Published: Nov. 10, 2020, 5:02 a.m.
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SapL1: A New Target Lectin for the Development of Antiadhesive Therapy Against Scedosporium apiospermum

Published: Nov. 10, 2020, 4:01 a.m.
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Highly potent bispecific sybodies neutralize SARS-CoV-2

Published: Nov. 10, 2020, 3:01 a.m.
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Structure, interdomain dynamics and pH-dependent autoactivation of pro-rhodesain, the main lysosomal cysteine protease from African trypanosomes

Published: Nov. 10, 2020, 1:01 a.m.
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SARS-CoV-2 epitope mapping on microarrays highlights strong immune-response to N protein region

Published: Nov. 9, 2020, 10:02 p.m.
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The DEAD-box RNA helicase Ded1 from yeast is associated with the signal recognition particle and is regulated by SRP21

Published: Nov. 9, 2020, 2:01 p.m.
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Sequential dynamics of Stearoyl-CoA Desaturase-1 (SCD1) ligand binding and unbinding mechanism: A computational study

Published: Nov. 9, 2020, 7:01 a.m.
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Computationally-guided design and affinity improvement of a protein binder targeting a specific site on HER2

Published: Nov. 9, 2020, 4:02 a.m.
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Sphingolipid changes in Parkinson L444P GBA mutation fibroblasts promote α-synuclein aggregation

Published: Nov. 9, 2020, 4:01 a.m.
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Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

Published: Nov. 9, 2020, 3:01 a.m.
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Assembly of higher-order SMN oligomers is essential for metazoan viability and requires an exposed structural motif present in the YG zipper dimer

Published: Nov. 8, 2020, 8:03 p.m.
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Acute radiofrequency electromagnetic radiation exposures cause neuronal DNA damage and impair neurogenesis in the young adolescent rat brain

Published: Nov. 8, 2020, 8:03 p.m.
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Molecular Elucidation of Pancreatic Elastase Inhibition by Baicalein

Published: Nov. 8, 2020, 12:01 p.m.
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Visualising Cholesterol in Brain by On-Tissue Derivatisation and Quantitative Mass Spectrometry Imaging

Published: Nov. 7, 2020, 10:02 a.m.
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Fluorescent Antibody Multiplexing with Oligo-Based Combinatorial Labeling

Published: Nov. 7, 2020, 10:02 a.m.
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Finger Sweat Analysis Enables Short Interval Metabolic Biomonitoring in Humans

Published: Nov. 7, 2020, 10:01 a.m.
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Acrylamide Fragment Inhibitors that Induce Unprecedented Conformational Distortions in Enterovirus 71 3C and SARS-CoV-2 Main Protease

Published: Nov. 6, 2020, 9:01 p.m.
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Extraction and Characterization of Rice Bran Polysaccharides and Their Derivative Preparation and Antioxidant Activity

Published: Nov. 6, 2020, 7:01 a.m.
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Phosphonate production by marine microbes: exploring new sources and potential function

Published: Nov. 5, 2020, 11:02 p.m.
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A combined flow injectionreversed phase chromatography - high resolution mass spectrometry workflow for accurate absolute lipid quantification with 13C- internal standards

Published: Nov. 5, 2020, 8:03 p.m.
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High-level expression of the monomeric SARS-CoV-2 S-protein RBD 320-537 in stably transfected CHO cells by the EEF1A1-based plasmid vector.

Published: Nov. 5, 2020, 10:02 a.m.
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GR chaperone cycle mechanism revealed by cryo-EM: inactivation of GR by GR:Hsp90:Hsp70:Hop client-loading complex

Published: Nov. 5, 2020, 4:01 a.m.
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A Fast Lysine Cross-linker DOPA Enables Mass Spectrometry Analyses of Protein Unfolding and Weak Protein-protein Interactions

Published: Nov. 5, 2020, 2:02 a.m.
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Modelling the active SARS-CoV-2 helicase complex as a basis for structure-based inhibitor design

Published: Nov. 3, 2020, 11:01 p.m.
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Isolation and biophysical characterization of GSU0105, a triheme c-type cytochrome from Geobacter sulfurreducens

Published: Nov. 3, 2020, 4:02 a.m.
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Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+, Causes Reductive Stress, and Suppresses Glycolysis and Cell Growth

Published: Nov. 3, 2020, 4:02 a.m.
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Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

Published: Nov. 3, 2020, 4:02 a.m.
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Genome information processing by the INO80 chromatin remodeler positions nucleosomes

Published: Nov. 3, 2020, 4:02 a.m.
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The ACE2-binding interface of SARS-CoV-2 Spike inherently deflects immune recognition

Published: Nov. 3, 2020, 12:01 a.m.
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Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA.

Published: Nov. 2, 2020, 3:02 p.m.
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Direct detection of coupled proton and electron transfers in human manganese superoxide dismutase

Published: Nov. 2, 2020, 4:02 a.m.
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Standard Procedures for Native CZE-MS of Proteins and Protein Complexes up to 800 kDa

Published: Nov. 2, 2020, 3:03 a.m.
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Adipose Triglyceride Lipase is needed for homeostatic control of Sterol Element-Binding Protein-1c driven hepatic lipogenesis

Published: Nov. 2, 2020, 3:03 a.m.
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TMPRSS2 and ADAM17 interactions with ACE2 complexed with SARS-CoV-2 and B0AT1 putatively in intestine, cardiomyocytes, and kidney

Published: Nov. 1, 2020, 10:01 p.m.
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Paper-based Sensing of Fucosylated Biological Compounds

Published: Nov. 1, 2020, 12:03 p.m.
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In-vitro and Insilico screening platform for the identification of aldose reductase inhibitors for antidiabetic lead compounds from Abutilon Indicum (L.)

Published: Nov. 1, 2020, 12:03 p.m.
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Singe cell oil (SCO) based bioactive compounds: II. Enzymatic synthesis of glucose fatty acid esters using SCOs as acyl group-donors and their biological activities

Published: Nov. 1, 2020, 11:01 a.m.
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Structural Basis of Stu2 Recruitment to Yeast Kinetochores

Published: Nov. 1, 2020, 10:01 a.m.
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Rational tuning of a membrane-perforating antimicrobial peptide to selectively target membranes of different lipid composition

Published: Nov. 1, 2020, 6:01 a.m.
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Mutations in an intracellular vestibule that bifurcates from the pore of ClC-1 chloride ion channels affect anion permeation

Published: Nov. 1, 2020, 6:01 a.m.
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Structure of Gcn1 bound to stalled and colliding 80S ribosomes

Published: Oct. 31, 2020, 11:01 p.m.
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HP1 proteins compact DNA into mechanically and positionally stable phase separated domains

Published: Oct. 31, 2020, 10:01 p.m.
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DNA ligase I fidelity mediates the mutagenic ligation of pol β oxidized nucleotide insertion products and base excision repair intermediates with mismatches

Published: Oct. 31, 2020, 6:02 p.m.
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The DNA binding domain of the Vibrio vulnificus SmcR transcription factor is flexible and recognizes diverse DNA sequences

Published: Oct. 31, 2020, 9:01 a.m.
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Revisiting the phosphotyrosine binding pocket of Fyn SH2 domain led to the Identification of novel SH2 superbinders

Published: Oct. 30, 2020, 10:01 p.m.
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Structure of the enterococcal T4SS protein PrgL reveals unique dimerization interface in the VirB8 protein family

Published: Oct. 30, 2020, 3:03 p.m.
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Structure-based functional study of a peptide of an ecdysozoan superfamily: reveling a common molecular architecture and receptor-interacting residues

Published: Oct. 30, 2020, 1:01 p.m.
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New cinnamid and rosmarinic acid-derived compounds biosynthesized in Escherichia coli as Leishmania amazonensis arginase inhibitors

Published: Oct. 30, 2020, 4:01 a.m.
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Quantifying signal persistence in the T cell signaling network using an optically controllable antigen receptor

Published: Oct. 30, 2020, 3:01 a.m.
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Amino acid transporter B0AT1 influence on ADAM17 interactions with SARS-CoV-2 receptor ACE2 putatively expressed in intestine, kidney, and cardiomyocytes

Published: Oct. 30, 2020, 1:01 a.m.
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COVID Moonshot: Open Science Discovery of SARS-CoV-2 Main Protease Inhibitors by Combining Crowdsourcing, High-Throughput Experiments, Computational Simulations, and Machine Learning

Published: Oct. 30, 2020, 1:01 a.m.
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Structural basis for a natural circular permutation in proteins

Published: Oct. 29, 2020, 6:02 p.m.
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Kinetic isotope tracing of glycerol and de novo proteogenic amino acids in Human Lung Carcinoma cells using glucose

Published: Oct. 28, 2020, 6:02 p.m.
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Assessment of fasting blood glucose, serum electrolyte, albumin,creatinin, urea and lipid profile among hypertensive patients and non-hypertensive participants at wolaita sodo university teaching and referral hospital, SNNPR, Ethiopia

Published: Oct. 28, 2020, 4:01 p.m.
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High-throughput fluorescent assay for inhibitor screening of proteases from RNA viruses

Published: Oct. 28, 2020, 2:01 p.m.
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Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

Published: Oct. 28, 2020, 4:02 a.m.
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Mechanism of SARS-CoV-2 polymerase inhibition by remdesivir

Published: Oct. 28, 2020, 3:01 a.m.
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A new twist of rubredoxin function in M. tuberculosis

Published: Oct. 27, 2020, 7:03 p.m.
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Di(2-ethylhexyl) adipate (DEHA), A NEW HOPE!A sustainable and promising process for the plasticisers industry

Published: Oct. 27, 2020, 7:03 p.m.
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Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis

Published: Oct. 27, 2020, 6:01 a.m.
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High catalytic rate of the cold-active Vibrio alkaline phosphatase depends on a hydrogen bonding network involving a large interface loop

Published: Oct. 27, 2020, 4:02 a.m.
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Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains

Published: Oct. 26, 2020, 2:01 p.m.
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Distinct autoinhibitory mechanisms regulate vinculin binding by alpha-T-catenin and alpha-E-catenin

Published: Oct. 26, 2020, 2:01 p.m.
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CaMKII binds both substrates and effectors at the active site

Published: Oct. 26, 2020, 8:01 a.m.
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A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells

Published: Oct. 24, 2020, 6:01 a.m.
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Specificities of modeling membrane proteins using multi-template homology modeling

Published: Oct. 23, 2020, 12:04 a.m.
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Creation and analysis of enzymatically active micrometer protein-capsules

Published: Oct. 22, 2020, 9:01 p.m.
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Yeast Ssd1 is a non-enzymatic member of the RNase II family with an alternative RNA recognition interface

Published: Oct. 22, 2020, 7:02 p.m.
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Structural basis of inhibition of a putative drug efflux transporter NorC, through a single-domain camelid antibody

Published: Oct. 22, 2020, 7:02 p.m.
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Transport of Alzheimer's Associated Amyloid-β Catalyzed by P-glycoprotein

Published: Oct. 22, 2020, 5:01 a.m.
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Mammalian Cell Proliferation Requires Noncatalytic Functions of O-GlcNAc Transferase

Published: Oct. 22, 2020, 5:01 a.m.
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Biogenesis of NDUFS3-less complex I indicates TMEM126AOPA7 as an assembly factor of the ND4-module

Published: Oct. 22, 2020, 4:03 a.m.
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Stretch and Twist of HEAT Repeats Leads to Activation of DNA-PK Kinase

Published: Oct. 21, 2020, 3:01 p.m.
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Structure of the light harvesting 2 complex reveals two carotenoid energy transfer pathways in a photosynthetic bacterium

Published: Oct. 21, 2020, 7:02 a.m.
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The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

Published: Oct. 21, 2020, 6:02 a.m.
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Molecular determinants for α-tubulin methylation by SETD2

Published: Oct. 21, 2020, 6:02 a.m.
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Epistasis shapes the fitness landscape of an allosteric specificity switch

Published: Oct. 21, 2020, 5:02 a.m.
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Biochemical Validation of a Fourth Guanidine Riboswitch Class in Bacteria

Published: Oct. 21, 2020, 4:02 a.m.
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Stability of the Retinoid X Receptor-alpha Homodimer in the Presence and Absence of Rexinoid and Coactivator Peptide

Published: Oct. 21, 2020, 3:05 a.m.
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Proteomics study of colorectal cancer and adenomatous polyps identifies TFR1, SAHH, and HV307 as potential biomarkers for screening

Published: Oct. 20, 2020, 9:01 a.m.
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Membrane-Dependent Amyloid Aggregation of Human BAX α9 (173-192)

Published: Oct. 20, 2020, 5:01 a.m.
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Self-Organized Amphiphiles are Poor Hydroxyl Radical Scavengers in Fast Photochemical Oxidation of Proteins Experiments

Published: Oct. 20, 2020, 5:01 a.m.
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Kinetic and thermodynamic analysis defines roles for two metal ions in DNA polymerase specificity and catalysis

Published: Oct. 20, 2020, 4:01 a.m.
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Structural coordination between active sites of a Cas6-reverse transcriptase-Cas1--Cas2 CRISPR integrase complex

Published: Oct. 19, 2020, 10:01 p.m.
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Mapping sites of carboxymethyllysine modification on proteins reveals its consequences for proteostasis and cell proliferation

Published: Oct. 19, 2020, 4:01 p.m.
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Dihydro-alpha-lipoic acid binds to human serum albumin at Sudlow I binding site

Published: Oct. 19, 2020, 4:01 p.m.
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Investigation of biochemical changes in barley inoculated with Trichoderma harzianum T-22 under salt stress

Published: Oct. 19, 2020, 5:02 a.m.
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An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

Published: Oct. 19, 2020, 4:01 a.m.
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Photochemical probe identification of the small-molecule binding site in a mammalian membrane-bound O-acyltransferase

Published: Oct. 17, 2020, 11:02 a.m.
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Explore the Potential of a Plant Phospholipase as an Antimicrobial

Published: Oct. 17, 2020, 7:02 a.m.
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SARS-CoV-2 S protein ACE2 interaction reveals novel allosteric targets

Published: Oct. 16, 2020, 4:02 p.m.
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Extension of a de novo TIM barrel with a rationally designed secondary structure element

Published: Oct. 16, 2020, 5:02 a.m.
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A paired liver biopsy and plasma proteomics study reveals circulating biomarkers for alcohol-related liver disease

Published: Oct. 16, 2020, 1:01 a.m.
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A high throughput RNA displacement assay for screening SARS-CoV-2 nsp10-nsp16 complex towards developing therapeutics for COVID-19

Published: Oct. 15, 2020, 11:01 p.m.
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Inhibition of SARS-CoV-2 viral entry in vitro upon blocking N- and O-glycan elaboration

Published: Oct. 15, 2020, 11:01 p.m.
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Mechanisms of allosteric and mixed mode aromatase inhibitors

Published: Oct. 15, 2020, 5:01 a.m.
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iTRAQ-Based Proteomic Profiling of PLC-Mediated Expression of 20E-Induced Protein in Apolygus lucorum (Meyer-Dür)

Published: Oct. 15, 2020, 5:01 a.m.
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An improved comprehensive strategy for deep and quantitative N-glycomics based on optimization of sample preparation, isotope-based data quality control and quantification, new N-glycan libraries and new algorithms

Published: Oct. 15, 2020, 5:01 a.m.
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C9orf72- derived proline:arginine poly-dipeptides disturb cytoskeletal architecture

Published: Oct. 15, 2020, 2:02 a.m.
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The Effects of Inter-Individual Biological Differences and Taphonomic Alteration on Human Bone Protein Profiles: Implications for the Development of PMIAAD Estimation Methods

Published: Oct. 15, 2020, 2:02 a.m.
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Homology Initialization for Protein Structure Determination via Distance Geometry

Published: Oct. 15, 2020, 1:02 a.m.
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Comparison of Extracellular Vesicle Isolation Methods from Human Biofluids using Single Molecule Arrays

Published: Oct. 14, 2020, 11:02 p.m.
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Stalling chromophore maturation of the fluorescent protein Venus reveals the molecular basis of the final oxidation step

Published: Oct. 14, 2020, 9:02 p.m.
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Structural analysis of rice Os4BGlu18 monolignol β-glucosidase

Published: Oct. 14, 2020, 7:01 a.m.
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Structural characterization of HIV-1 matrix mutants implicated in envelope incorporation

Published: Oct. 14, 2020, 12:03 a.m.
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ACIS, A Novel KepTide™, Binds to ACE-2 Receptor and Inhibits the Infection of SARS-CoV2 Virus in vitro in Primate Kidney Cells: Therapeutic Implications for COVID-19

Published: Oct. 14, 2020, 12:03 a.m.
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Structural impact on SARS-CoV-2 spike protein by D614G substitution

Published: Oct. 13, 2020, 5:01 a.m.
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Listed in: Science

Mapping the substrate sequence and length of the Plasmodium M1 and M17 aminopeptidases

Published: Oct. 13, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Mycobacterial surface-associated ESX-1 virulence factors play a role in mycobacterial adherence and invasion into lung epithelial cells

Published: Oct. 13, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Colitis is associated with loss of LHPP and up-regulation of histidine phosphorylation in intestinal epithelial cells

Published: Oct. 11, 2020, 4:01 p.m.
Duration: N/A

Listed in: Science

Structural Perturbations of Exon Skipping Edits within the Dystrophin D20:24 Region

Published: Oct. 11, 2020, 4:01 p.m.
Duration: N/A

Listed in: Science

Expansion of gamma-butyrolactone signaling molecule biosynthesis to phosphotriester natural products

Published: Oct. 11, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

Bio-Orthogonal Chemistry Enables Solid Phase Synthesis of Long RNA Oligonucleotides

Published: Oct. 10, 2020, 10:04 a.m.
Duration: N/A

Listed in: Science

Dynamic binning peak detection and assessment of various lipidomics liquid chromatography-mass spectrometry pre-processing platforms

Published: Oct. 10, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Mutations in SKI in Shprintzen-Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

Published: Oct. 9, 2020, 4:02 p.m.
Duration: N/A

Listed in: Science

Bacterial precursors and unsaturated long-chain fatty acids are biomarkers of North-Atlantic demosponges

Published: Oct. 9, 2020, 8:02 a.m.
Duration: N/A

Listed in: Science

Adeno-associated virus capsid assembly is divergent and stochastic

Published: Oct. 9, 2020, 4:01 a.m.
Duration: N/A

Listed in: Science

Adsorption mechanism of bacteria onto a Na-montmorillonite surface with organic and inorganic calcium

Published: Oct. 9, 2020, 1:04 a.m.
Duration: N/A

Listed in: Science

Genome engineering of Nannochloropsis with large deletions for constructing microalgal minigenomes

Published: Oct. 9, 2020, 1:04 a.m.
Duration: N/A

Listed in: Science

Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimers disease brain

Published: Oct. 8, 2020, 8:02 a.m.
Duration: N/A

Listed in: Science

Preferential recognition and antagonism of SARS-CoV-2 spike glycoprotein binding to 3-O-sulfated heparan sulfate

Published: Oct. 8, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Catechol-Containing Compounds are a Broad Class of Amyloid Inhibitors: I. Redox State is a Key Determinant of the Activities of the Inhibitory Activities

Published: Oct. 8, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Sleuthing biochemical evidence to elucidate unassigned electron density in a CBLSLAP2 crystal complex

Published: Oct. 8, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Metal Dependent Dynamic Equilibrium: A Regulatory Mechanism for M17 Aminopeptidases from Plasmodium falciparum and Plasmodium vivax

Published: Oct. 8, 2020, 3:02 a.m.
Duration: N/A

Listed in: Science

Discriminative SKP2 interactions with CDK-cyclin complexes support a cyclin A-specific role in p27KIP1 degradation

Published: Oct. 8, 2020, 3:02 a.m.
Duration: N/A

Listed in: Science

Mass spectrometry imaging of phosphatidylcholine metabolism in lungs administered with therapeutic surfactants and isotopic tracers

Published: Oct. 7, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2

Published: Oct. 7, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

NSP 11 of SARS-CoV-2 is an Intrinsically Disordered Protein

Published: Oct. 7, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Recapitulating the frataxin activation mechanism in an engineered bacterial cysteine desulfurase supports the architectural switch model

Published: Oct. 6, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

The structure of Rns from enterotoxigenic Escherichia coli reveals a small molecule inhibitor

Published: Oct. 6, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Transmembrane polar relay drives the allosteric regulation for ABCG5G8 sterol transporter

Published: Oct. 6, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Cytoplasmic short linear motifs in ACE2 and integrin beta3 link SARS-CoV-2 host cell receptors to endocytosis and autophagy

Published: Oct. 6, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

The sandarazols are cryptic and structurally unique plasmid encoded toxins from a rare myxobacterium

Published: Oct. 6, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Oligomerisation of THAP9 transposase: role of DNA and amino-terminal domains

Published: Oct. 6, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Activation of the membrane-bound Nrf1 transcription factor by USP19, a tail-anchored ubiquitin-specific protease in the endoplasmic reticulum

Published: Oct. 6, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Benchmarking non-targeted metabolomics using yeast derived libraries

Published: Oct. 6, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

The electrostatic allostery could be the trigger for the changes in dynamics for the PDZ domain of PICK1

Published: Oct. 6, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

The contribution of PARP1, PARP2 and poly(ADP-ribosyl)ation to base excision repair in the nucleosomal context

Published: Oct. 5, 2020, 7:01 p.m.
Duration: N/A

Listed in: Science

Evolution of molecular determinants for SUMO-activating enzyme subcellular localization in plants

Published: Oct. 5, 2020, 7:01 p.m.
Duration: N/A

Listed in: Science

Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model

Published: Oct. 5, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

Precision targeting of the Plasminogen Activator Inhibitor-1 mechanism increases efficacy of fibrinolytic therapy in empyema.

Published: Oct. 5, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Hsf1 is SUMOylated in the activated trimeric state

Published: Oct. 5, 2020, 1:03 a.m.
Duration: N/A

Listed in: Science

β-Amyloid peptides tailor switching behaviors of Donor-Acceptor Stenhouse Adducts

Published: Oct. 5, 2020, 1:03 a.m.
Duration: N/A

Listed in: Science

Validated B vitamin quantification from lentils by ultra-performance liquid chromatography selected reaction monitoring mass spectrometry

Published: Oct. 4, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Development and validation of nanobodies specific to the oncogenic phosphatase Protein Tyrosine Phosphatase 4A3 (PTP4A3 or PRL-3)

Published: Oct. 3, 2020, 9:03 a.m.
Duration: N/A

Listed in: Science

Spectrin Interactome under normal and HbE-disease conditions

Published: Oct. 3, 2020, 5:02 a.m.
Duration: N/A

Listed in: Science

NT-mini, a recombinant tool for the study of Neurotrypsin functionality

Published: Oct. 2, 2020, 3:01 p.m.
Duration: N/A

Listed in: Science

Structural basis for recruitment of the CHK1 DNA damage kinase by the CLASPIN scaffold protein

Published: Oct. 2, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

The X-linked intellectual disability gene product and E3 ubiquitin ligase KLHL15 degrades doublecortin proteins to constrain neuronal dendritogenesis

Published: Oct. 2, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

The Phaeodactylum tricornutum Diaminopimelate Decarboxylase was Acquired via Horizontal Gene Transfer from Bacteria and Displays Substrate Promiscuity

Published: Oct. 2, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Epistasis on the stability landscape of de novo TIM barrels explored by a modular design approach

Published: Oct. 1, 2020, 7:03 p.m.
Duration: N/A

Listed in: Science

Lipid-bound ApoE3 self-assemble into elliptical disc-shaped particles

Published: Oct. 1, 2020, 7:03 p.m.
Duration: N/A

Listed in: Science

Ribosome assembly factors modulate the RNA folding landscape to prevent misfolding

Published: Oct. 1, 2020, 7:03 p.m.
Duration: N/A

Listed in: Science

Brazilin Removes Toxic alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

Published: Oct. 1, 2020, 7:02 p.m.
Duration: N/A

Listed in: Science

Regulation of kinase activity by combined action of juxtamembrane and C-terminal regions of receptors

Published: Oct. 1, 2020, 3:02 p.m.
Duration: N/A

Listed in: Science

Proteoglycan 4 (PRG4) expression and functionin dry eye associated inflammation

Published: Oct. 1, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Reconfiguring Okazaki fragment start sites on a genome by using a data driven approach

Published: Sept. 30, 2020, 2:01 p.m.
Duration: N/A

Listed in: Science

Reengineering the Specificity of the Highly Selective Clostridium botulinum Protease via Directed Evolution

Published: Sept. 30, 2020, 5:02 a.m.
Duration: N/A

Listed in: Science

Structural insights on the substrate-binding proteins of the Mycobacterium tuberculosis mammalian-cell-entry (Mce) 1 and 4 complexes

Published: Sept. 30, 2020, 5:02 a.m.
Duration: N/A

Listed in: Science

Herbal medicine of Kursi Wufarikun Ziyabit inhibits mitochondrial ATP production to activate AMPK in hepatocytes in therapy of type 2 diabetes

Published: Sept. 29, 2020, 5:01 p.m.
Duration: N/A

Listed in: Science

CDK-Mediated Phosphorylation of FANCD2 Promotes Mitotic Fidelity

Published: Sept. 29, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

A synthetic small molecule stalls pre-mRNA splicing by promoting an early-stage U2AF2-RNA complex

Published: Sept. 29, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Light-induced modulation of DNA recognition by the Rad4XPC damage sensor protein

Published: Sept. 29, 2020, 2:01 a.m.
Duration: N/A

Listed in: Science

Tethering-facilitated DNA 'opening' and complementary roles of β-hairpin motifs in the Rad4XPC DNA damage sensor protein

Published: Sept. 29, 2020, 2:01 a.m.
Duration: N/A

Listed in: Science

Design, expression, purification and characterization of a YFP-tagged 2019-nCoV spike receptor-binding domain construct

Published: Sept. 29, 2020, 1:01 a.m.
Duration: N/A

Listed in: Science

Attempted fractionation of LB Lennox medium via reversed phase high performance liquid chromatography

Published: Sept. 28, 2020, 11:02 p.m.
Duration: N/A

Listed in: Science

Understanding the compositional changes in LB Lennox medium during growth of Escherichia coli DH5α in a 1L bioreactor

Published: Sept. 28, 2020, 2:01 p.m.
Duration: N/A

Listed in: Science

Evolution of Modularity, Interactome and Functions of GIVGirdin (CCDC88A) from Invertebrates to Vertebrates

Published: Sept. 28, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

ISRIB blunts the integrated stress response by allosterically antagonising the inhibitory effect of phosphorylated eIF2 on eIF2B

Published: Sept. 28, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

GHB confers neuroprotection by stabilizing the CaMKIIα hub domain

Published: Sept. 28, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Regulation of cGAS activity through RNA-mediated phase separation

Published: Sept. 28, 2020, 2:03 a.m.
Duration: N/A

Listed in: Science

Enhanced retinoid response by a combination of the vitamin A ester retinyl propionate with niacinamide and a flavonoid containing Ceratonia siliqua extract in retinoid responsive in vitro models.

Published: Sept. 27, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Mg2+-binding shifts the IM30 activity from membrane protection to membrane destabilization

Published: Sept. 26, 2020, 6:01 p.m.
Duration: N/A

Listed in: Science

The vitamin A ester retinyl propionate has a unique metabolic profile and higher retinoid-related bioactivity over retinol and retinyl palmitate in human skin models.

Published: Sept. 26, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Primary saturation of α,β-unsaturated carbonyl containing fatty acids does not abolish electrophilicity

Published: Sept. 25, 2020, 11:02 p.m.
Duration: N/A

Listed in: Science

Beam image-shift accelerated data acquisition for near-atomic resolution single-particle cryo-electron tomography

Published: Sept. 25, 2020, 6:02 p.m.
Duration: N/A

Listed in: Science

First 3D-Structural Data of Full-length Rod-Outer-Segment Guanylyl Cyclase 1 in Bovine Retina by Cross-linkingMass Spectrometry

Published: Sept. 25, 2020, 5:02 p.m.
Duration: N/A

Listed in: Science

Pentapeptide repeat proteins QnrB1 and AlbG require ATP hydrolysis to rejuvenate poisoned gyrase complexes

Published: Sept. 25, 2020, 5:02 p.m.
Duration: N/A

Listed in: Science

Structural insights into F-actin regulation and sarcomere assembly via myotilin

Published: Sept. 25, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

METTL3 inhibitors for epitranscriptomic modulation of cellular processes

Published: Sept. 25, 2020, 5:02 a.m.
Duration: N/A

Listed in: Science

Structure and substrate specificity determinants of the taurine biosynthetic enzyme cysteine sulphinic acid decarboxylase

Published: Sept. 25, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2

Published: Sept. 25, 2020, 12:03 a.m.
Duration: N/A

Listed in: Science

Harnessing Ionic Selectivity In Acetyltransferase Chemoproteomic Probes

Published: Sept. 25, 2020, 12:03 a.m.
Duration: N/A

Listed in: Science

The ER chaperones BiP and Grp94 regulate the formation of insulin-like growth factor 2 (IGF2) oligomers

Published: Sept. 25, 2020, 12:03 a.m.
Duration: N/A

Listed in: Science

Changes in biochemistry and histochemical characteristics during somatic embryogenesis in Ormosia henryi Prain

Published: Sept. 24, 2020, 3:01 p.m.
Duration: N/A

Listed in: Science

HIF1a-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia

Published: Sept. 24, 2020, 3:01 p.m.
Duration: N/A

Listed in: Science

Structural biologists, lets mind our colors

Published: Sept. 24, 2020, 10:01 a.m.
Duration: N/A

Listed in: Science

Nature-inspired Circular-economy Recycling (NaCRe) for Proteins: Proof of Concept

Published: Sept. 24, 2020, 3:01 a.m.
Duration: N/A

Listed in: Science

Structure and mechanism of human dual oxidase 1 complex

Published: Sept. 23, 2020, 4:01 p.m.
Duration: N/A

Listed in: Science

Resolving atomic site interactions of the Y. pestis outer membrane protein Ail with human serum in the bacterial cell envelope

Published: Sept. 23, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor.

Published: Sept. 22, 2020, 3:01 p.m.
Duration: N/A

Listed in: Science

Active focus stabilization for fluorescence microscopy by tracking actively generated infrared spots.

Published: Sept. 22, 2020, 8:03 a.m.
Duration: N/A

Listed in: Science

Targeting Allostery in the Dynein Motor Domain with Small Molecule Inhibitors

Published: Sept. 22, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice

Published: Sept. 22, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Therapeutic inhibition of keratinocyte TRPV3 sensory channels by local anesthetic dyclonine

Published: Sept. 22, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Protonation states in SARS-CoV-2 main protease mapped by neutron crystallography

Published: Sept. 22, 2020, 1:01 a.m.
Duration: N/A

Listed in: Science

Engineering protein-specific proteases: targeting active RAS

Published: Sept. 21, 2020, 7:01 p.m.
Duration: N/A

Listed in: Science

Modelling locust foraging: How and why food affects hopper band formation

Published: Sept. 21, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

An Interpreted Atlas of Biosynthetic Gene Clusters from 1000 Fungal Genomes

Published: Sept. 21, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function

Published: Sept. 21, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Experimental and computational studies on molecular mechanism by which Curcumin allosterically inhibits Dengue protease

Published: Sept. 21, 2020, 12:01 a.m.
Duration: N/A

Listed in: Science

Proteasome Regulation by Reversible Tyrosine Phosphorylation at the Membrane

Published: Sept. 20, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Fast and easy single-molecule pulldown assay based on agarose microbeads

Published: Sept. 20, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Periplasmic Expression of SpyTagged Antibody Fragments Enables Rapid Modular Antibody Assembly

Published: Sept. 20, 2020, 1:03 a.m.
Duration: N/A

Listed in: Science

Adaptation of a microfluidic qPCR system for enzyme kinetics studies

Published: Sept. 20, 2020, 12:04 a.m.
Duration: N/A

Listed in: Science

Selective metal ion utilization contributes to the transformation of the activity of yeast polymerase η from DNA polymerization toward RNA polymerization

Published: Sept. 20, 2020, 12:04 a.m.
Duration: N/A

Listed in: Science

Cell type-selective secretome profiling in vivo

Published: Sept. 20, 2020, 12:04 a.m.
Duration: N/A

Listed in: Science

The mobility of interfaces between monomers in dimeric bovine ATP synthase participates in the ultrastructure of inner mitochondrial membranes

Published: Sept. 20, 2020, 12:04 a.m.
Duration: N/A

Listed in: Science

Dimerization mechanism and structural features of human LI-cadherin

Published: Sept. 20, 2020, 12:04 a.m.
Duration: N/A

Listed in: Science

F-domain valency determines outcome of signaling through the angiopoietin pathway

Published: Sept. 19, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

Insulin inhibits protein phosphatase 2A to impair β-adrenergic receptor function

Published: Sept. 19, 2020, 5:03 a.m.
Duration: N/A

Listed in: Science

Insight into glycosphingolipid crypticity: Crystal structure of the anti-tumor antibody 14F7 and recognition of NeuGc GM3 ganglioside

Published: Sept. 18, 2020, 7:01 p.m.
Duration: N/A

Listed in: Science

Identification and Characterization of a Residual Host Cell Protein Hexosaminidase B Associated with N-glycan Degradation During the Stability Study of a Therapeutic Recombinant Monoclonal Antibody Product

Published: Sept. 18, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

A dual-reporter system for investigating and optimizing protein translation and folding in E. coli

Published: Sept. 18, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Histidine-rich Ca2+-binding protein stimulates the transport cycle of SERCA through a conformation-dependent fuzzy complex.

Published: Sept. 18, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Optic Atrophy-associated TMEM126A is an assembly factor for the ND4-module of Mitochondrial Complex I

Published: Sept. 18, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

beta-blocker reverses inhibition of beta-2 adrenergic receptor resensitization by hypoxia

Published: Sept. 18, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Phase Separation Can Increase Enzyme Activity by Concentration and Molecular Organization

Published: Sept. 17, 2020, 8:02 p.m.
Duration: N/A

Listed in: Science

Association of protein concentration and enzyme AChE activity in plasma and whole blood samples with physical activity in healthy elderly individuals

Published: Sept. 17, 2020, 8:02 p.m.
Duration: N/A

Listed in: Science

Lactose intolerance: Magnitude and Associated factors among malnourished under-five Children in Yekatit 12 Hospital Medical College, Addis Ababa, Ethiopia

Published: Sept. 17, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

THE IMPACT OF THE HYDROXYMETHYLCYTOSINE EPIGENETIC SIGNATURE ON DNA STRUCTURE AND FUNCTION

Published: Sept. 17, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Actin-binding compounds that affect the kinetics of the interaction of cardiac myosin with actin

Published: Sept. 17, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

The eukaryotic replisome requires an additional helicase to disarm dormant replication origins

Published: Sept. 17, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Impairment in O-acetylserine-(thiol) lyase A and B, but not C, confers higher selenate sensitivity and uncovers role for A, B and C as L-Cys and L-SeCys desulfhydrases in Arabidopsis

Published: Sept. 17, 2020, 2:03 a.m.
Duration: N/A

Listed in: Science

Structural and Functional Comparison of SARS-CoV-2-Spike Receptor Binding Domain Produced in Pichia pastoris and Mammalian Cells

Published: Sept. 17, 2020, 1:01 a.m.
Duration: N/A

Listed in: Science

Multiple pathways of toxicity induced by C9orf72 dipeptide repeat aggregates and G4C2 RNA in a cellular model

Published: Sept. 16, 2020, 3:02 p.m.
Duration: N/A

Listed in: Science

DMA-tudor interaction modules control the specificity of in vivo condensates

Published: Sept. 16, 2020, 10:03 a.m.
Duration: N/A

Listed in: Science

Identifying HIV-1 RNA splice variant protein interactomes using HyPR-MSSV

Published: Sept. 16, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Dynamic analysis of sugar metabolism reveals the mechanisms of action of synthetic sugar analogs

Published: Sept. 16, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Targeted Proteomics Reveals Quantitative Differences in Low Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation

Published: Sept. 16, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Inhibition of Streptococcus pneumoniae autolysins highlight distinct differences between chemical and genetic inactivation

Published: Sept. 16, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Ebselen, disulfiram, carmofur, PX-12, tideglusib, and shikonin are non-specific promiscuous SARS-CoV-2 main protease inhibitors

Published: Sept. 16, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Rational design of a new class of protease inhibitors for the potential treatment of coronavirus diseases

Published: Sept. 15, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Heme oxygenase-1 affects cytochrome P450 function through the formation of heteromeric complexes: Interactions between CYP1A2 and heme oxygenase-1

Published: Sept. 14, 2020, 11:01 p.m.
Duration: N/A

Listed in: Science

The DNA Damage-Sensing NER Repair Factor XPC-RAD23B Does Not Recognize Bulky DNA Lesions with a Missing Nucleotide Opposite the Lesion.

Published: Sept. 14, 2020, 9:01 p.m.
Duration: N/A

Listed in: Science

Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid

Published: Sept. 14, 2020, 6:02 p.m.
Duration: N/A

Listed in: Science

Enzymatic synthesis of fatty acid amides using microbial lipids as acyl group-donors and their biological activities

Published: Sept. 13, 2020, 2:01 a.m.
Duration: N/A

Listed in: Science

Fine interaction profiling of VemP and mechanisms responsible for its translocation-coupled arrest-cancelation

Published: Sept. 12, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

Human trans-editing enzyme displays tRNA acceptor stem specificity and relaxed amino acid selectivity

Published: Sept. 11, 2020, 11:01 p.m.
Duration: N/A

Listed in: Science

Phosphodiesterase Type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins.

Published: Sept. 11, 2020, 5:04 p.m.
Duration: N/A

Listed in: Science

TTAPE-Me dye is not selective to cardiolipin and responds to main anionic phospholipids unspecifically

Published: Sept. 11, 2020, 5:04 p.m.
Duration: N/A

Listed in: Science

Nicotinamide mononucleotide (NMN) de-amidation by the gut microbiome and evidence for indirect upregulation of the NAD+ metabolome

Published: Sept. 11, 2020, 5:04 p.m.
Duration: N/A

Listed in: Science

Kinetic-Mechanistic Evidence for Which E. coli RNA Polymerase-{lambda}PR Open Promoter Complex Initiates and for Stepwise Disruption of Contacts in Bubble Collapse

Published: Sept. 11, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity

Published: Sept. 11, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Semi-processive hyperglycosylation of adhesin by bacterial protein N-glycosyltransferases

Published: Sept. 10, 2020, 4:01 p.m.
Duration: N/A

Listed in: Science

Evidence for conformational change-induced hydrolysis of β-tubulin-GTP

Published: Sept. 10, 2020, 2:01 p.m.
Duration: N/A

Listed in: Science

Structural basis for binding mechanism of human serum albumin complexed with cyclic peptide dalbavancin

Published: Sept. 10, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

The inhibitory activity of GlyT2 targeting bioactive lipid analgesics are influenced by formation of a deep lipid cavity

Published: Sept. 10, 2020, 8:02 a.m.
Duration: N/A

Listed in: Science

Glycosyltransferase POMGNT1 deficiency affects N-cadherin-mediated cell-cell adhesion

Published: Sept. 10, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

Switch-1 Instability at the Active Site Decouples ATP Hydrolysis from Force Generation in Myosin II

Published: Sept. 10, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement

Published: Sept. 10, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

ARL15 modulates magnesium homeostasis through N-glycosylation of CNNMs

Published: Sept. 10, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

CLPX regulates erythroid heme synthesis by control of mitochondrial heme synthesis enzymes and iron utilization

Published: Sept. 9, 2020, 8:02 a.m.
Duration: N/A

Listed in: Science

Predominant activation of 11-oxygenated androgens by peripheral blood mononuclear cells

Published: Sept. 9, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

Untangling mechanisms of crude oil toxicity in a cold water fish via gene expression, morphology and PAHs at two developmental stages

Published: Sept. 9, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

Time-dependent changes to sepsis-specific networks in the plasma proteome are mechanistic readouts of sepsis progression.

Published: Sept. 9, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Candidate screening of host cell membrane proteins involved in SARS-CoV-2 entry

Published: Sept. 9, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Decoding the Protein Composition of Whole Nucleosomes with Nuc-MS

Published: Sept. 8, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

UVA radiation could be a significant contributor to sunlight inactivation of SARS-CoV-2

Published: Sept. 8, 2020, 12:01 a.m.
Duration: N/A

Listed in: Science

Discovery of a Potent and Dual-Selective Bisubstrate Inhibitor for Protein Arginine Methyltransferase 45

Published: Sept. 6, 2020, 5:02 a.m.
Duration: N/A

Listed in: Science

Saccharomyces cerevisiae Ecm2 Modulates the Catalytic Steps of pre-mRNA Splicing

Published: Sept. 5, 2020, 6:02 a.m.
Duration: N/A

Listed in: Science

Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

Published: Sept. 5, 2020, 4:01 a.m.
Duration: N/A

Listed in: Science

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation

Published: Sept. 4, 2020, 7:04 p.m.
Duration: N/A

Listed in: Science

Depsipeptide nucleic acids: prebiotic formation, oligomerization, and self-assembly of a new candidate proto-nucleic acid

Published: Sept. 4, 2020, 2:01 p.m.
Duration: N/A

Listed in: Science

Hydrogen-deuterium exchange reveals a dynamic DNA binding map of Replication Protein A

Published: Sept. 4, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

Chemical validation of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase using fragment linking and CRISPR interference

Published: Sept. 4, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

Evolutionarily conserved chaperone-mediated proteasomal degradation of a disease-linked aspartoacylase variant

Published: Sept. 4, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Mitochondrial, cell cycle control and neuritogenesis alterations in an iPSC-based neurodevelopmental model for schizophrenia

Published: Sept. 4, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Structural basis for bacterial ribosome quality control

Published: Sept. 3, 2020, 6:02 p.m.
Duration: N/A

Listed in: Science

Peroxisomes contribute to intracellular calcium dynamics

Published: Sept. 3, 2020, 5:02 p.m.
Duration: N/A

Listed in: Science

The Epidermal Barrier is Indispensable for Systemic Energy Homeostasis

Published: Sept. 3, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Amyloid particles facilitate surface-catalyzed cross-seeding by acting as promiscuous nanoparticles

Published: Sept. 3, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Evaluating Inositol phospholipid interactions with Inward Rectifier Potassium Channels and characterising their role in Disease

Published: Sept. 3, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

SUMO Modifies GβL and Mediates mTOR Signaling

Published: Sept. 3, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Discovery and characterization of llama VHH targeting the RO form of human CD45

Published: Sept. 2, 2020, 10:02 a.m.
Duration: N/A

Listed in: Science

SPECIES-DEPENDENT HETEROPHILIC AND HOMOPHILIC CADHERIN INTERACTIONS IN INTESTINAL INTERMICROVILLAR LINKS

Published: Sept. 2, 2020, 10:02 a.m.
Duration: N/A

Listed in: Science

BonA from Acinetobacter baumannii forms a divisome-localized decamer that supports outer envelope function

Published: Sept. 2, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Tapping into a phospholipid-LRH-1 axis yields a powerful anti-inflammatory agent with in vivo activity against colitis

Published: Sept. 1, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Exploring the conformational landscape of a lanthipeptide synthetase using native mass spectrometry

Published: Sept. 1, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

eEF2 kinase enhances the expression of PD-L1 by promoting the translation of its mRNA

Published: Sept. 1, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Energy-dependent protein folding: modeling how a protein-folding machine may work

Published: Sept. 1, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing

Published: Sept. 1, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Strong reduction of the chain rigidity of hyaluronan by selective binding of Ca2+ ions

Published: Sept. 1, 2020, 3:01 a.m.
Duration: N/A

Listed in: Science

Identification of Lysine Isobutyrylation as A New Histone Modification Mark

Published: Sept. 1, 2020, 2:02 a.m.
Duration: N/A

Listed in: Science

Branching microtubule nucleation is controlled by importin-mediated inhibition of TPX2 phase separation

Published: Sept. 1, 2020, 1:01 a.m.
Duration: N/A

Listed in: Science

DIAFree enables untargeted open-search identification for Data-Independent Acquisition data

Published: Aug. 31, 2020, 11:02 p.m.
Duration: N/A

Listed in: Science

N-glucosyltransferase GbNGT1 from Ginkgo complement auxin metabolic pathway

Published: Aug. 31, 2020, 10:01 p.m.
Duration: N/A

Listed in: Science

Ribosome inhibition by C9ORF72-ALSFTD-associated poly-PR and poly-GR proteins revealed by cryo-EM

Published: Aug. 31, 2020, 6:01 p.m.
Duration: N/A

Listed in: Science

A novel SHAPE reagent enables the analysis of RNA structure in living cells with unprecedented accuracy

Published: Aug. 31, 2020, 5:01 p.m.
Duration: N/A

Listed in: Science

Assembly of bacterial cell division protein FtsZ into dynamic biomolecular condensates

Published: Aug. 31, 2020, 3:01 p.m.
Duration: N/A

Listed in: Science

AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation

Published: Aug. 31, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

Complex effects of pH on ROS from mitochondrial complex II driven complex I reverse electron transport challenge its role in tissue reperfusion injury

Published: Aug. 31, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Ebselen derivatives are very potent dual inhibitors of SARS-CoV-2 proteases - PLpro and Mpro in in vitro studies

Published: Aug. 31, 2020, 2:01 a.m.
Duration: N/A

Listed in: Science

On-rate modulation of cadherin interactions by chemical fragments

Published: Aug. 31, 2020, 1:03 a.m.
Duration: N/A

Listed in: Science

Structure-Altering Mutations of the SARS-CoV-2 Frame Shifting RNA Element

Published: Aug. 30, 2020, 11:01 p.m.
Duration: N/A

Listed in: Science

A Liquid-to-Solid Phase Transition Enhances the Catalytic Activity of SARM1

Published: Aug. 29, 2020, 10:01 a.m.
Duration: N/A

Listed in: Science

Future carbon emissions from global mangrove forest loss

Published: Aug. 29, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Establishment of murine hybridoma cells producing antibodies against spike protein of SARS-CoV-2

Published: Aug. 29, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Two bi-functional cytochrome P450 CYP72 enzymes from olive (Olea europaea) catalyze the oxidative C-C bond cleavage in the biosynthesis of secoxy-iridoids - flavor and quality determinants in olive oil

Published: Aug. 28, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

Pathogenic Mechanisms Underlying Stargardt Macular Degeneration Linked to Mutations in the Transmembrane Domains of ABCA4

Published: Aug. 28, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

A DNA nanoscope that identifies and precisely localizes over a hundred unique molecular features with nanometer accuracy

Published: Aug. 28, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

Activation mechanism of a small prototypic Rec-GGDEF diguanylate cyclase

Published: Aug. 28, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry (CE-ESI-MS)

Published: Aug. 28, 2020, 2:01 a.m.
Duration: N/A

Listed in: Science

Base Pairing and Functional Insights into N3-methylcytidine (m3C) in RNA

Published: Aug. 28, 2020, 2:01 a.m.
Duration: N/A

Listed in: Science

Nonclassical nucleation of protein mesocrystals via oriented attachment

Published: Aug. 27, 2020, 10:02 p.m.
Duration: N/A

Listed in: Science

A biophysical and structural analysis of DNA binding by oligomeric hSSB1 (NABP2OBFC2B)

Published: Aug. 27, 2020, 9:01 p.m.
Duration: N/A

Listed in: Science

Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

Published: Aug. 27, 2020, 8:02 p.m.
Duration: N/A

Listed in: Science

Hydroxylation of antitubercular drug candidate, SQ109, by mycobacterial cytochrome P450

Published: Aug. 27, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Rapid in vitro prototyping of O-methyltransferases for pathway applications in Escherichia coli

Published: Aug. 27, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

SARS-CoV-2 Nucleocapsid protein is decorated with multiple N- and O-glycans.

Published: Aug. 27, 2020, 12:01 a.m.
Duration: N/A

Listed in: Science

Cryo-electron microscopy structures of pyrene-labeled ADP-Pi- and ADP-actin filaments

Published: Aug. 26, 2020, 11:01 p.m.
Duration: N/A

Listed in: Science

A CRISPR Screen Identifies Myc-associated Zinc Finger Protein (MAZ) as an Insulator Functioning at CTCF boundaries in Hox Clusters

Published: Aug. 26, 2020, 8:01 p.m.
Duration: N/A

Listed in: Science

Employing scan-SCAM to identify residues that compose transmembrane helix 1 (TM1) of EnvZ

Published: Aug. 25, 2020, 6:02 p.m.
Duration: N/A

Listed in: Science

Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair

Published: Aug. 25, 2020, 3:01 p.m.
Duration: N/A

Listed in: Science

Stimulation of the human mitochondrial transporter ABCB10 by zinc-mesoporphrin

Published: Aug. 25, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

Discovery of 5,5'-methylenedi-2,3-cresotic acid as a potent inhibitor of the HMGB1CXCL12 heterocomplex using Virtual Screening and NMR validation

Published: Aug. 25, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Transport mechanism of class-3 P4 ATPase lipid flippases

Published: Aug. 25, 2020, 12:01 a.m.
Duration: N/A

Listed in: Science

Structural basis for the allosteric regulation of Human Topoisomerase 2α

Published: Aug. 24, 2020, 11:01 p.m.
Duration: N/A

Listed in: Science

Biophysical characterization of the ETV6 PNT domain polymerization interfaces

Published: Aug. 24, 2020, 9:01 p.m.
Duration: N/A

Listed in: Science

On the diversity of F420-dependent oxidoreductases: a sequence- and structure-based classification

Published: Aug. 24, 2020, 9:01 p.m.
Duration: N/A

Listed in: Science

Modular metabolite assembly in C. elegans lysosome-related organelles

Published: Aug. 24, 2020, 8:02 p.m.
Duration: N/A

Listed in: Science

Synthesis and Evaluation of a Stable Isostere of Malonyllysine

Published: Aug. 24, 2020, 8:02 p.m.
Duration: N/A

Listed in: Science

How to limit the speed of a motor: The intricate regulation of the XPB ATPase and Translocase in TFIIH

Published: Aug. 24, 2020, 7:02 p.m.
Duration: N/A

Listed in: Science

Formation of an Aminovinyl-Cysteine Residue in Thioviridamide Non-Lanthipeptides Occurs through a Path Independent of Known Lanthionine Synthetase Activity in Streptomyces sp. NRRL S-87

Published: Aug. 24, 2020, 5:01 p.m.
Duration: N/A

Listed in: Science

Bacterial-like nonribosomal peptide synthetases produce cyclopeptides in the zygomycetous fungus Mortierella alpina

Published: Aug. 24, 2020, 3:01 p.m.
Duration: N/A

Listed in: Science

Discovery and Development of Novel DNA-PK Inhibitors by Targeting the unique Ku-DNA Interaction

Published: Aug. 24, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Methylmalonic acid compromises mitochondrial respiration and reduces the expression of markers of differentiation in SH-SY5Y human neuroblastoma cells

Published: Aug. 24, 2020, 12:01 a.m.
Duration: N/A

Listed in: Science

Evolution of dynamical networks enhances catalysis in a designer enzyme

Published: Aug. 23, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Solution structures of the Shewanella woodyi H-NOX protein in the presence and absence of soluble guanylyl cyclase stimulator IWP-051

Published: Aug. 23, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Cryo-EM Structures of HIV-1 trimer bound to CD4-mimetics M48U1 and BNM-III-170 adopt a CD4-bound open conformation

Published: Aug. 22, 2020, 9:02 a.m.
Duration: N/A

Listed in: Science

A sort-seq approach to the development of single fluorescent protein biosensors

Published: Aug. 22, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Structural basis for the activation of CDK7 by MAT1 and Cyclin H

Published: Aug. 21, 2020, 3:01 p.m.
Duration: N/A

Listed in: Science

Lanthipeptide Synthetases Participate the Biosynthesis of 2-Aminovinyl-Cysteine Motifs in Thioamitides

Published: Aug. 21, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Phase separation by the Sterile Alpha Motif of Polyhomeotic compartmentalizes Polycomb Group proteins and enhances their activity

Published: Aug. 21, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

A simple, high-throughput method of protein and label removal from extracellular vesicle samples

Published: Aug. 21, 2020, 7:02 a.m.
Duration: N/A

Listed in: Science

PeptideMind: applying machine learning algorithms to assess replicate quality in shotgun proteomic data

Published: Aug. 21, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

4 β-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor.

Published: Aug. 21, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

Troxerutin acts on complement mediated inflammation to ameliorate arthritic symptoms in rats.

Published: Aug. 20, 2020, 8:01 p.m.
Duration: N/A

Listed in: Science

Computational approach and functional analysis of Pectobacterium carotovorum subsp. carotovorum low-molecular weight bacteriocin Carocin S2

Published: Aug. 20, 2020, 5:02 p.m.
Duration: N/A

Listed in: Science

CRISPR-Cas9-mediated depletion of O-GlcNAc hydrolase and transferase for functional dissection of O-GlcNAcylation in human cells

Published: Aug. 20, 2020, 3:01 p.m.
Duration: N/A

Listed in: Science

Chloride-dependent conformational changes in the GlyT1 glycine transporter

Published: Aug. 20, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

A Multi-pronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization

Published: Aug. 20, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

A computationally designed fluorescent biosensor for D-serine

Published: Aug. 19, 2020, 8:03 p.m.
Duration: N/A

Listed in: Science

Optogenetic activation of heterotrimeric Gi proteins by LOV2GIVe - a rationally engineered modular protein

Published: Aug. 19, 2020, 7:01 p.m.
Duration: N/A

Listed in: Science

Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

Published: Aug. 18, 2020, 6:01 p.m.
Duration: N/A

Listed in: Science

Structural defects caused by Acrodermatitis Enteropathica mutations in the extracellular domain account for mistrafficking and malfunction of ZIP4

Published: Aug. 18, 2020, 3:02 p.m.
Duration: N/A

Listed in: Science

Structure and mechanism of a phage-encoded SAM lyase revises catalytic function of enzyme family

Published: Aug. 18, 2020, 3:02 p.m.
Duration: N/A

Listed in: Science

A High-Performance Genetically Encoded Fluorescent Biosensor for Imaging Physiological Peroxynitrite

Published: Aug. 18, 2020, 3:02 p.m.
Duration: N/A

Listed in: Science

Role of necroptosis in chronic hepatic inflammation and liver disease in CuZn superoxide dismutase deficient mice

Published: Aug. 18, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

A Novel Stress Response Pathway Regulates Ribosome Biogenesis

Published: Aug. 17, 2020, 10:01 p.m.
Duration: N/A

Listed in: Science

Inhibition of mTOR decreases insoluble protein burden by reducing translation in C. elegans

Published: Aug. 17, 2020, 8:01 p.m.
Duration: N/A

Listed in: Science

LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications

Published: Aug. 17, 2020, 5:01 p.m.
Duration: N/A

Listed in: Science

Alternative catalytic mechanisms driven by structural plasticity is an emerging theme in HAS-GTPases, Era and FeoB

Published: Aug. 17, 2020, 5:01 p.m.
Duration: N/A

Listed in: Science

Sweet chirality: the taste of L and D glucose stereoisomers

Published: Aug. 17, 2020, 4:01 p.m.
Duration: N/A

Listed in: Science

Synthesis and in vitro Activity of Eugenyl Benzoate Derivatives as BCL-2 Inhibitor in Colorectal Cancer with QSAR and Molecular Docking Approach

Published: Aug. 17, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

Enhancers regulate polyadenylation site cleavage and control 3'UTR isoform expression

Published: Aug. 17, 2020, 8:01 a.m.
Duration: N/A

Listed in: Science

Vesicle capture by discrete self-assembled clusters of membrane-bound Munc13

Published: Aug. 17, 2020, 6:01 a.m.
Duration: N/A

Listed in: Science

The adaptor protein NumbL is involved in the control of glucolipotoxicity-induced pancreatic beta cell apoptosis

Published: Aug. 16, 2020, 7:01 a.m.
Duration: N/A

Listed in: Science

Structural evolution of the tissue-specific U2AF2 paralog and alternative splicing factor LS2

Published: Aug. 15, 2020, 5:01 a.m.
Duration: N/A

Listed in: Science

Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 main protease by tafenoquine in vitro

Published: Aug. 15, 2020, 1:01 a.m.
Duration: N/A

Listed in: Science

The proteasome-related Connectase is a fast and specific protein ligase

Published: Aug. 14, 2020, 11:02 p.m.
Duration: N/A

Listed in: Science

The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures

Published: Aug. 14, 2020, 11:01 p.m.
Duration: N/A

Listed in: Science

Use of target-displaying magnetized yeast in screening mRNA display peptide libraries to identify ligands

Published: Aug. 14, 2020, 5:01 p.m.
Duration: N/A

Listed in: Science

Structural insights into the interaction of heme with protein tyrosine kinase JAK2

Published: Aug. 14, 2020, 5:01 p.m.
Duration: N/A

Listed in: Science

Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

Published: Aug. 14, 2020, 4:02 p.m.
Duration: N/A

Listed in: Science

Designed Variants of Recombinant ACE2-Fc that Decouple Anti-SARS-CoV-2 Activities from Unwanted Cardiovascular Effects

Published: Aug. 14, 2020, 2:01 a.m.
Duration: N/A

Listed in: Science

Alteration of mucins in the submandibular gland during aging in mice

Published: Aug. 13, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Quantitative yeast-yeast two hybrid for discovery and binding affinity estimation of protein-protein interactions

Published: Aug. 13, 2020, 9:01 a.m.
Duration: N/A

Listed in: Science

Characterisation of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification

Published: Aug. 13, 2020, 1:01 a.m.
Duration: N/A

Listed in: Science

Bimodal evolution of Src and Abl kinase substrate specificity revealed using mammalian cell extract as substrate pool

Published: Aug. 12, 2020, 4:01 a.m.
Duration: N/A

Listed in: Science

Kinesin-1 motility traced by an activity-based precipitating dye

Published: Aug. 12, 2020, 4:01 a.m.
Duration: N/A

Listed in: Science

PCNA monoubiquitination is regulated by diffusion of Rad6Rad18 complexes along RPA filaments

Published: Aug. 12, 2020, 2:05 a.m.
Duration: N/A

Listed in: Science

Conformational changes and channel gating induced by CO2 binding to Connexin26

Published: Aug. 12, 2020, 1:01 a.m.
Duration: N/A

Listed in: Science

Single amino acid-promoted reactions link a non-enzymatic chemical network to the early evolution of enzymatic pentose phosphate pathway

Published: Aug. 12, 2020, 1:01 a.m.
Duration: N/A

Listed in: Science

Temporal modulation of the NF-κB RelA network in response to different types of DNA damage

Published: Aug. 11, 2020, 2:02 p.m.
Duration: N/A

Listed in: Science

AsterixGtsf1 links tRNAs and piRNA silencing of retrotransposons

Published: Aug. 11, 2020, 2:02 p.m.
Duration: N/A

Listed in: Science

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15

Published: Aug. 11, 2020, 2:02 p.m.
Duration: N/A

Listed in: Science

Discovery and biosynthesis of clostyrylpyrones from the obligate an-aerobe Clostridium roseum

Published: Aug. 11, 2020, 2:01 p.m.
Duration: N/A

Listed in: Science