Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.21.214403v1?rss=1 Authors: Hunyady, J. P. Abstract: The present paper represents a hypothetical structure, the structure for energy transformation (SET), and its proposed evolution, which might be responsible for the proper energy transformation steps leading to the continuous production of H+ and ATP in living cells. We predict that the electron flow is realized through the electron flow device (EFD). We suppose that there are several versions of the SET with three of them being described below. The hypothesis is based on the properties of the atoms of the protonated adenine molecule and docking computations of molecular mechanics involved, suggesting that two ascorbate molecules may occupy the empty NADPH pocket, preferably binding to the adenine binding site. We hypothesize that the adenine originates from uric acid (UA), resulting in an ATP-UA-ADP-ATP cycle. It would also mean that UA is one of the oxygen carriers in aerobic glycolysis. We also suppose that the EFD contains the well-known molecules and clusters of the electron transport chain supplemented with two additional UA originated adenine molecules and two L-ascorbic acid molecules. Based on all this, we surmise that a tetra adenine octo phosphate ring (TAR) exists, in which the UA originated adenine molecules form a ring. The molecules are linked to each other through the N7-C2 and C8-N1 atoms of the adenine molecules by H2PO4e- molecules. The four N10 atoms of the adenine molecules bind one flavin, one nicotinamide, and two L-ascorbic acid molecules. Six D-glucose molecules complete one unit of the structure. Both Fe-S and cytochrome clusters and dehydrogenases ensure the continuous operation of the unit. Eukaryotic cells are equipped with the mechanisms of the SET, using aerobic glycolysis of Warburg and the SET of oxidative phosphorylation; thus, they can live in an anoxic environment as well. It is hoped that the concept of the SET developed here will help to better understand the complex process of energy transformation. Copy rights belong to original authors. Visit the link for more info