Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.08.285221v1?rss=1 Authors: Pimienta, G. Abstract: Sepsis accounts for 1 in 5 deaths globally and is the most common cause of deaths in U.S. hospitals. Despite this public health burden, no diagnostic biomarker, nor therapeutic agent for sepsis has proven useful or effective. The principal obstacle is the lack of a mechanistic understanding of this syndrome, particularly during its onset and progression. Using an experimental model of murine sepsis, we report here a time-dependent assessment of changes to the plasma proteome upon infection with Salmonella enterica serovar Typhimurium. Changes to the inflammatory cytokine response and the plasma proteome signature of sepsis (PPSS) revealed a transition from early inflammation and coagulation to a later stage of chronic inflammation, cytokine storm, coagulopathy and bacteremia. This study represents an advance in our understanding of sepsis progression that may guide innovative therapeutic approaches and help clinicians track sepsis progression. Copy rights belong to original authors. Visit the link for more info