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Last Sunday, I briefly mentioned a paper concerning a ketone metabolite known as beta-hydroxybutyrate, or BHB, and its ability to block the activity of a set of inflammatory genes. This particular set of genes, known as the NLRP3 inflammasome, has been linked to Alzheimer\u2019s disease, atherosclerosis, metabolic syndrome, and age-related macular degeneration. In other words, it\u2019s in our best interest to avoid its chronic, pathogenic activation, and it looks like going into ketosis can probably help in that respect.

One thing led to another, and this paper got me thinking: once we \u201cgo into ketosis,\u201d how long should we stay? If some is good, is more better? Is there a point where the benefits slow and the downsides accrue?

(This Mark's Daily Apple article was written by Mark Sisson, and is narrated by Brock Armstrong)