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In this podcast, Mark Sisson explains how appetite supersedes the oversimplified equation of calories in = calories out, and how optimizing hormones and gene expression is the true path to effortless lifelong weight management. Mark discusses how moderating insulin production is the key to lifelong weight control, for it unlocks the potential to minimize reliance on ingested calories in favor of burning stored body fat and ketones for energy. Optimizing insulin also regulates appetite hormones such as leptin and ghrelin, and enables you to obtain the fat reduction and cellular repair benefits associated with Intermittent Fasting.