BROADCASTS.com

b'\\u67d3\\u8272\\u4f53\\u5206\\u914d\\u6642\\u306b\\u304a\\u3051\\u308bKi-67\\u306e\\u6a5f\\u80fd\\u6027\\u306b\\u95a2\\u3059\\u308b\\u8ad6\\u6587\\u3092\\u7d39\\u4ecb\\u3057\\u307e\\u3057\\u305f\\u3002

Show notes

\\n
• \\u5468\\u671f\\u30bc\\u30df
\\n
• Periodical cicadas \\u2026 \\u5168\\u7c73\\u306b\\u304a\\u3051\\u308b\\u5468\\u671f\\u30bc\\u30df\\u306e\\u5206\\u5e03\\u306b\\u3064\\u3044\\u3066
\\n
• \\u8ad6\\u6587\\u306e\\u7e26\\u8aad\\u307f \\u2026 \\u540c\\u3058\\u30aa\\u30fc\\u30b5\\u30fc\\u306e\\u8ad6\\u6587\\u3092\\u6642\\u9593\\u8ef8\\u3067\\u8aad\\u3080\\u3001\\u8ad6\\u6587\\u306e\\u7e26\\u8aad\\u307f\\u306b\\u3064\\u3044\\u3066\\u306fresearchat.fm\\u306eep57\\u306b\\u3066\\u8aac\\u660e\\u3057\\u307e\\u3057\\u305f\\u3002
\\n
• Cuylen-Haering et al., Nature (2020) \\u2026 \\u201cChromosome clustering by Ki-67 excludes cytoplasm during nuclear assembly\\u201d
\\n
• Gerlich et al. Cell (2003) \\u2026 \\u201cGlobal Chromosome Positions Are Transmitted through Mitosis in Mammalian Cells\\u201d
\\n
• Cuylen et al., Nature (2016) \\u2026 \\u201cKi-67 acts as a biological surfactant to disperse mitotic chromosomes\\u201d
\\n
• Samwer et al., Cell (2017) \\u2026 \\u201cDNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes\\u201d
\\n
• Daniel Gerlich
\\n
• \\u690d\\u7269\\u306e\\u7d30\\u80de\\u3067\\u67d3\\u8272\\u4f53\\u304c\\u5206\\u914d\\u3055\\u308c\\u308b\\u69d8\\u5b50 \\u2026 1956\\u306b\\u64ae\\u5f71\\u3055\\u308c\\u305fAfrican Blood Lily\\u306e\\u7d30\\u80de\\u306b\\u304a\\u3051\\u308b\\u67d3\\u8272\\u4f53\\u5206\\u914d\\u3068\\u7d30\\u80de\\u5206\\u88c2\\u306e\\u69d8\\u5b50\\u3002\\u690d\\u7269\\u306b\\u306f\\u4e2d\\u5fc3\\u4f53\\u304c\\u5b58\\u5728\\u3057\\u306a\\u3044\\u306e\\u3067\\u5c11\\u3057\\u52d5\\u7269\\u7d30\\u80de\\u306e\\u3082\\u306e\\u3068\\u306f\\u8da3\\u304c\\u7570\\u306a\\u308b\\u300264\\u5e74\\u524d\\u306b\\u64ae\\u5f71\\u3055\\u308c\\u305f\\u52d5\\u753b\\u3060\\u304c\\u672a\\u3060\\u8272\\u892a\\u305b\\u305a\\u69d8\\u3005\\u306a\\u6d1e\\u5bdf\\u3092\\u4e0e\\u3048\\u3066\\u304f\\u308c\\u308b\\u3002\\u7121\\u67d3\\u8272\\u30fb\\u30e9\\u30a4\\u30d6\\u30bb\\u30eb\\u3067\\u884c\\u308f\\u308c\\u305f\\u9a5a\\u7570\\u7684\\u306a\\u30a4\\u30e1\\u30fc\\u30b8\\u30f3\\u30b0\\u3002
\\n
• \\u4e0a\\u8a18\\u52d5\\u753b\\u306b\\u95a2\\u3059\\u308b\\u30c4\\u30a4\\u30fc\\u30c8 \\u2026 \\u6d77\\u5916\\u52e2\\u3082\\u304b\\u306a\\u308a\\u30b3\\u30e1\\u30f3\\u30c8\\u3092\\u304f\\u308c\\u3066\\u3044\\u308b\\u306e\\u304c\\u308f\\u304b\\u308b\\u3002
\\n
• \\u4f53\\u7d30\\u80de\\u5206\\u88c2 \\u2026 prophase->prometaphase->metaphase->anaphase->telophase->cytokinesis\\u3002\\u82f1\\u8a9e\\u3060\\u3068mitosis
\\n
• DNA\\u8907\\u88fd
\\n
• \\u907a\\u4f1d\\u60c5\\u5831
\\n
• \\u6e1b\\u6570\\u5206\\u88c2 \\u2026 \\u82f1\\u8a9e\\u3060\\u3068meiosis
\\n
• HeLa\\u7d30\\u80de
\\n
• \\u67d3\\u8272\\u4f53
\\n
• \\u6838(\\u7d30\\u80de\\u6838)
\\n
• \\u30df\\u30c8\\u30b3\\u30f3\\u30c9\\u30ea\\u30a2 \\u2026 \\u30d1\\u30e9\\u30b5\\u30a4\\u30c8\\u30fb\\u30a4\\u30f4\\u3067\\u3054\\u5b58\\u77e5\\u306e\\u65b9\\u3082\\u591a\\u3044\\u3060\\u308d\\u3046\\u3002
\\n
• \\u7d30\\u80de\\u5c0f\\u5668\\u5b98
\\n
• \\u6838\\u5c0f\\u4f53 \\u2026 \\u4ec1\\u3068\\u3082\\u547c\\u3070\\u308c\\u3066\\u3044\\u305f\\u3002
\\n
• \\u30ea\\u30dc\\u30bd\\u30fc\\u30e0
\\n
• \\u30ea\\u30dc\\u30bd\\u30fc\\u30e0RNA
\\n
• \\u500d\\u6570\\u6027
\\n
• \\u59c9\\u59b9\\u67d3\\u8272\\u4f53/\\u59c9\\u59b9\\u67d3\\u8272\\u5206\\u4f53
\\n
• \\u30b3\\u30d2\\u30fc\\u30b7\\u30f3 \\u2026 \\u59c9\\u59b9\\u67d3\\u8272\\u4f53\\u3092\\u63a5\\u7740\\u3055\\u305b\\u308b\\u305f\\u3081\\u306b\\u91cd\\u8981\\u306a\\u30bf\\u30f3\\u30d1\\u30af\\u8cea
\\n
• Locke. JCS (1990) \\u2026 \\u201cIs there somatic inheritance of intracellular patterns?\\u201d
\\n
• transvection
\\n
• mitophagy
\\n
• \\u30d2\\u30b9\\u30c8\\u30f3
\\n
• \\u30cc\\u30af\\u30ec\\u30aa\\u30bd\\u30fc\\u30e0
\\n
• \\u30af\\u30ed\\u30de\\u30c1\\u30f3 \\u2026 \\u30d2\\u30b9\\u30c8\\u30f3\\u3001\\u30cc\\u30af\\u30ec\\u30aa\\u30bd\\u30fc\\u30e0\\u3001\\u30af\\u30ed\\u30de\\u30c1\\u30f3\\u3001\\u67d3\\u8272\\u4f53\\u306b\\u3064\\u3044\\u3066\\u306f\\u3069\\u3053\\u304b\\u3067\\u3058\\u3063\\u304f\\u308a\\u8a71\\u3057\\u307e\\u3059\\u3002
\\n
• CFP, YFP \\u2026 \\u86cd\\u5149\\u30bf\\u30f3\\u30d1\\u30af\\u8cea
\\n
• \\u7d30\\u80de\\u5468\\u671f \\u2026 G1->S->G2->M. G1->S->G2\\u304c\\u9593\\u671f\\u3001M\\u304c\\u5206\\u88c2\\u671f
\\n
• FRAP(Fluorescence recovery after photobleaching)
\\n
• FISH
\\n
• Kimura and Cook. J Cell Biol (2001) \\u2026 \\u201cKinetics of core histones in living human cells: little exchange of H3 and H4 and some rapid exchange of H2B\\u201d
\\n
• \\u67d3\\u8272\\u4f53\\u30c6\\u30ea\\u30c8\\u30ea\\u30fc
\\n
• Cremer and Cremer. Cold Spring Harb Perspect Biol. (2010) \\u2026 \\u201cChromosome Territories\\u201d: \\u30c9\\u30f3\\u30d4\\u30b7\\u30e3\\u30bf\\u30a4\\u30c8\\u30eb\\u306eThomas Cremer\\u306b\\u3088\\u308bChromosome territory\\u306e\\u30ec\\u30d3\\u30e5\\u30fc\\u3002
\\n
• Carl Rabl
\\n
• Theodor Boveri
\\n
• Sutton-Boveri\\u306e\\u67d3\\u8272\\u4f53\\u8aac
\\n
• \\u30ad\\u30cd\\u30c8\\u30b3\\u30a2
\\n
• \\u30bb\\u30f3\\u30c8\\u30ed\\u30e1\\u30a2
\\n
• \\u30b9\\u30d4\\u30f3\\u30c9\\u30eb \\u2026 \\u7d21\\u9318\\u4f53
\\n
• \\u5fae\\u5c0f\\u7ba1 \\u2026 microtuble
\\n
• RNAi
\\n
• ki-67
\\n
• G0\\u671f
\\n
• \\u6838\\u819c
\\n
• \\u6838\\u819c\\u5b54
\\n
• open mitosis/closed mitosis
\\n
• Nuclear envelope break down \\u2026 \\u6838\\u819c\\u306e\\u5d29\\u58ca
\\n
• \\u30ce\\u30b3\\u30c0\\u30be\\u30fc\\u30eb
\\n
• \\u30b3\\u30eb\\u30d2\\u30c1\\u30f3
\\n
• FCS
\\n
• \\u4e21\\u89aa\\u5a92\\u6027
\\n
• Crasta et al., Nature (2012) \\u2026 \\u201cDNA breaks and chromosome pulverization from errors in mitosis\\u201d micro nuclei\\u306b\\u95a2\\u3059\\u308b\\u6700\\u8fd1\\u306e\\u4ee3\\u8868\\u7684\\u306a\\u7814\\u7a76
\\n
• \\u30b9\\u30d7\\u30e9\\u30a4\\u30b7\\u30f3\\u30b0
\\n
• \\u30b3\\u30f3\\u30c7\\u30f3\\u30b7\\u30f3
\\n
• Delarue et al. Cell (2018) \\u2026 \\u201cmTORC1 Controls Phase Separation and the Biophysical Properties of the Cytoplasm by Tuning Crowding\\u201d: GEMs(genetically encoded multimeric nanoparticles)\\u3092\\u958b\\u767a\\u3057\\u305f\\u8ad6\\u6587\\u3002\\u3053\\u308c\\u306f\\u6fc0\\u30a2\\u30c4\\u3067\\u3042\\u308b\\uff01
\\n
• Akita et al., JCS (2007) \\u2026 \\u201cThe crystal structure of a virus-like particle from the hyperthermophilic archaeon Pyrococcus furiosus provides insight into the evolution of viruses\\u201d: Delarue et al. (2018)\\u3067\\u4f7f\\u308f\\u308c\\u305fencapsulin\\u306b\\u95a2\\u3059\\u308b\\u8ad6\\u6587\\u3002\\u3053\\u308c\\u3082\\u6fc0\\u30a2\\u30c4\\u3067\\u3042\\u308b\\uff01
\\n
• \\u990a\\u738b\\u7530\\u5148\\u751f\\u306e\\u79d1\\u7814\\u8cbb\\u5831\\u544a\\u66f8 \\u2026 \\u201cEncapsulin\\u3068\\u306f\\u5358\\u4e00\\u306e\\u30b7\\u30a7\\u30eb\\u30bf\\u30f3\\u30d1\\u30af\\u8cea\\u3067\\u69cb\\u6210\\u3055\\u308c\\u308b\\u5185\\u90e8\\u304c\\u7a7a\\u6d1e\\u306e\\u30ca\\u30ce\\u69cb\\u9020\\u4f53\\u3067\\u3042\\u308a\\u3001\\u4e00\\u90e8\\u306e\\u5fae\\u751f\\u7269\\u7d30\\u80de\\u5185\\u306b\\u5f62\\u6210\\u3055\\u308c\\u3066\\u3044\\u308b\\u3002\\u201d
\\n
• \\u6838\\u79fb\\u884c\\u30b7\\u30b0\\u30ca\\u30eb
\\n
• G\\xf6risch et al., JCS (2005) \\u2026 \\u201cHistone acetylation increases chromatin accessibility\\u201d: \\u30af\\u30ed\\u30de\\u30c1\\u30f3\\u3078\\u306eaccessibility\\u3092\\u30a4\\u30e1\\u30fc\\u30b8\\u30f3\\u30b0\\u3067\\u793a\\u305d\\u3046\\u3068\\u3057\\u305f\\u8ad6\\u6587
\\n
• Dextran
\\n
• Flavopiridol
\\n
• Trichostatin A (TSA)
\\n
• Angelika Amon
\\n
• Breakthrough Prize in Life Sciences
\\n
• \\u67d3\\u8272\\u4f53\\u306e\\u7570\\u6570\\u6027 \\u2026 aneuploidy
\\n
• \\u51fa\\u82bd\\u9175\\u6bcd
\\n
• U\\u0308nal et al., Science (2011) \\u2026 \\u201cGametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast\\u201d: \\u8001\\u5316\\u3057\\u305f\\u51fa\\u82bd\\u9175\\u6bcd\\u306f\\u6e1b\\u6570\\u5206\\u88c2\\u306b\\u9032\\u307f\\u306b\\u304f\\u3044\\u3053\\u3068\\u3092\\u793a\\u3057\\u305f\\u5b9a\\u91cf\\u89e3\\u6790\\u3002Amon lab\\u304b\\u3089\\u306e\\u7814\\u7a76\\u3002
\\n
• King et al., eLife (2019) \\u2026 \\u201cMeiotic cellular rejuvenation is coupled to nuclear remodeling in budding yeast\\u201d: \\u4e0a\\u8a18\\u306eFirst author\\u3067\\u3042\\u308bU\\u0308nal lab\\u304b\\u3089\\u51fa\\u305f\\u8ad6\\u6587\\u3002\\u5e74\\u8001\\u3044\\u305f\\u51fa\\u82bd\\u9175\\u6bcd\\u304c\\u6e1b\\u6570\\u5206\\u88c2\\u306b\\u9032\\u3093\\u3060\\u5834\\u5408\\u306e\\u201dNuclear rejuvenation\\u201d(\\u6838\\u82e5\\u8fd4\\u308a)\\u306b\\u95a2\\u3059\\u308b\\u30a4\\u30e1\\u30fc\\u30b8\\u30f3\\u30b0\\u7814\\u7a76
\\n
• \\u30a8\\u30d4\\u30b8\\u30a7\\u30cd\\u30c6\\u30a3\\u30af\\u30b9(epigenetics)
\\n
• Conrad Hal Waddington \\u2026 epigenetics\\u306e\\u63d0\\u5531\\u8005\\u3002
\\n

Editorial notes

\\n
• \\u7d20\\u4eba\\u306b\\u3082\\u30ed\\u30b8\\u30c3\\u30af\\u304c\\u8ffd\\u3044\\u3084\\u3059\\u304b\\u3063\\u305f\\u6c17\\u304c\\u3059\\u308b (soh)
\\n
• \\u7dbf\\u3005\\u3068\\u7d9a\\u304f\\u30c9\\u30a4\\u30c4\\u306e\\u7d30\\u80de\\u751f\\u7269\\u5b66/\\u67d3\\u8272\\u4f53\\u5b66\\u7814\\u7a76\\u306e\\u7cfb\\u8b5c\\u306f\\u307e\\u305f\\u3069\\u3053\\u304b\\u3067\\u8a71\\u305b\\u305f\\u3089\\u3068\\u601d\\u3044\\u307e\\u3059\\u3002(tadasu)
\\n
• figure\\u304c\\u30e2\\u30f3\\u30b9\\u30bf\\u30fc\\u30dc\\u30fc\\u30eb\\u307f\\u305f\\u3044\\u3067\\u3059\\u306d (coela)
\\n