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b'CRISPR-Cas9\\u4f7f\\u3063\\u305f\\u30b2\\u30ce\\u30e0\\u7de8\\u96c6\\u306e\\u6b74\\u53f2\\u3001Off-target\\u554f\\u984c\\u30011\\u5869\\u57fa\\u30b2\\u30ce\\u30e0\\u7de8\\u96c6\\u3001\\u30d0\\u30af\\u30c6\\u30ea\\u30a2\\u3078\\u306e\\u30c7\\u30fc\\u30bf\\u4fdd\\u5b58\\u3001Anti-CRISPR\\u30bf\\u30f3\\u30d1\\u30af\\u306a\\u3069\\u306b\\u3064\\u3044\\u3066\\u8a71\\u3057\\u307e\\u3057\\u305f\\u3002

Show notes

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• Multiplex Genome Engineering Using CRISPR/Cas Systems. Cong et al., Science 2012
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• RNA-Guided Human Genome Engineering via Cas9. Mali et al., Science 2012
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• Rationally engineered Cas9 nucleases with improved specificity. Slaymaker et al., Science 2016
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• High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. Kleinstiver et al., 2016 Nature
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• Ethics aside, does the CRISPR baby experiment make scientific sense?
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• \\u58f0\\u660e\\uff1a\\u30b2\\u30ce\\u30e0\\u7de8\\u96c6\\u3092\\u5b9f\\u65bd\\u3057\\u305f\\u30d2\\u30c8\\u53d7\\u7cbe\\u5375\\u304b\\u3089\\u5973\\u5150\\u3092\\u8a95\\u751f\\u3055\\u305b\\u305f\\u3068\\u306e\\u767a\\u8868\\u306b\\u5bfe\\u3059\\u308b\\u61f8\\u5ff5, \\u65e5\\u672c\\u30b2\\u30ce\\u30e0\\u7de8\\u96c6\\u5b66\\u4f1a
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• Guidelines for base editing in mammalian cells
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• CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Shipman et al., 2017 Nature
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• \\u30a6\\u30a7\\u30c3\\u30c8\\u306a\\u30c7\\u30fc\\u30bf\\u30b9\\u30c8\\u30ec\\u30fc\\u30b8\\u30e1\\u30c7\\u30a3\\u30a2\\u3068\\u3057\\u3066\\u306eDNA. \\u5b9f\\u9a13\\u533b\\u5b662019\\u5e741\\u6708\\u53f7
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• Naturally Occurring Off-Switches for CRISPR-Cas9. Pawluk et al., Cell 2016
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