b'\\u30c8\\u30ea\\u30d1\\u30ce\\u30bd\\u30fc\\u30de\\u306e\\u30ad\\u30cd\\u30c8\\u30b3\\u30a2\\u306b\\u3064\\u3044\\u3066\\u8a71\\u3057\\u307e\\u3057\\u305f\\u3002

Show notes

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• \\u30c8\\u30ea\\u30d1\\u30ce\\u30bd\\u30fc\\u30de
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• \\u30ad\\u30cd\\u30c8\\u30b3\\u30a2(\\u52d5\\u539f\\u4f53)
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• \\u30bb\\u30f3\\u30c8\\u30ed\\u30e1\\u30a2
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• Misleading Chat
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• 7. In the golden age of molecular biology (researchat.fm) \\u2026 \\u30b7\\u30c9\\u30cb\\u30fc\\u30fb\\u30d6\\u30ec\\u30ca\\u30fc\\u56de
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• 41. Single is not bad (researchat.fm)
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• Akiyoshist \\u2026 Akiyoshi\\u3055\\u3093\\u30d5\\u30a1\\u30f3\\u306e\\u547c\\u79f0
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• Akiyoshi Lab
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• Bungo Akiyoshi
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• \\u30cf\\u30eb\\u30ad\\u30b9\\u30c8
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• Akiyoshi and Gull. Cell (2014) \\u2026 Discovery of unconventional kinetochores in kinetoplastids
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• Tromer et al., Open Biology (2021) \\u2026 Repurposing of synaptonemal complex proteins for kinetochores in Kinetoplastida
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• \\u4f53\\u7d30\\u80de\\u5206\\u88c2 (mitosis)
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• \\u6e1b\\u6570\\u5206\\u88c2 (meiosis)
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• 2\\u500d\\u4f53
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• \\u76f8\\u540c\\u7d44\\u63db\\u3048
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• \\u76f8\\u540c\\u67d3\\u8272\\u4f53
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• \\u59c9\\u59b9\\u67d3\\u8272\\u4f53 \\u2026 sister chromatids
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• \\u30b3\\u30d2\\u30fc\\u30b7\\u30f3
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• \\u30b7\\u30ca\\u30d7\\u30c8\\u30cd\\u30de\\u30b3\\u30f3\\u30d7\\u30ec\\u30c3\\u30af\\u30b9
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• double strand break \\u2026 DNA\\u306e\\u4e8c\\u672c\\u9396\\u304c\\u5207\\u65ad\\u3055\\u308c\\u308b\\u3053\\u3068
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• Spo11
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• Bloomfield. Annu Rev Microbiol (2018) \\u2026 Dicty(\\u30ad\\u30a4\\u30ed\\u30bf\\u30de\\u30db\\u30b3\\u30ea\\u30ab\\u30d3)\\u306fspo11\\u304c\\u306a\\u3044\\u304c\\u3001\\u6e1b\\u6570\\u5206\\u88c2\\u6642\\u306b\\u76f8\\u540c\\u7d44\\u63db\\u3048\\u3092\\u884c\\u3046\\u3002
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• Cas9
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• DNA\\u30c8\\u30dd\\u30a4\\u30bd\\u30e1\\u30e9\\u30fc\\u30bc
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• \\u30ad\\u30a2\\u30ba\\u30de \\u2026 chiasma\\u3002chiasma\\u304c\\u306a\\u3044\\u6e1b\\u6570\\u5206\\u88c2\\u306e\\u3053\\u3068\\u3092achiasma\\u3068\\u547c\\u3076\\u3002
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• Rasmussen. Philos Trans R Soc Lond B Biol Sci. (1977) \\u2026 \\u201cMeiosis in Bombyx mori females\\u201d: \\u30ab\\u30a4\\u30b3\\u306e\\u30e1\\u30b9\\u3067\\u898b\\u3089\\u308c\\u308bachiasmata
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• John et al., Front Cell Dev Biol. (2016) \\u2026 \\u201cAchiasmy: Male Fruit Flies Are Not Ready to Mix\\u201d: \\u30cf\\u30a8\\u306e\\u30aa\\u30b9\\u306b\\u304a\\u3051\\u308bachiasmata\\u306b\\u95a2\\u3059\\u308b\\u7dcf\\u8aac
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• Xia et al., Genome Biology(2007) \\u2026 \\u30ab\\u30a4\\u30b3\\u306e\\u6027\\u7d30\\u80de\\u306b\\u304a\\u3051\\u308bspo11\\u767a\\u73fe\\u306e\\u8ad6\\u6587(Additional Data 5)
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• 48. XXXXXYYYYY (researchat.fm) \\u2026 \\u6027\\u306e\\u591a\\u69d8\\u6027\\u306b\\u3064\\u3044\\u3066\\u3002XY\\u3084ZW\\u578b\\u306b\\u3064\\u3044\\u3066\\u3082\\u89e3\\u8aac\\u3057\\u3066\\u3044\\u307e\\u3059\\u3002
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• Garg and Martin. Genome Biol. Evol. (2016) \\u2026 \\u201cMitochondria, the Cell Cycle, and the Origin of Sex via a Syncytial Eukaryote Common Ancestor\\u201d: mitosis\\u3068meiosis\\u306e\\u9032\\u5316\\u306b\\u3064\\u3044\\u3066
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• \\u6c34\\u7d20\\u4eee\\u8aac
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• William F Martin
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• Muller\\u2019s rachet
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• \\u6c34\\u5e73\\u4f1d\\u64ad(horizontal gene transfer)
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• \\u30a2\\u30d5\\u30ea\\u30ab\\u7761\\u7720\\u75c5
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• \\u30ca\\u30ac\\u30ca\\u75c5
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• \\u30c4\\u30a7\\u30c4\\u30a7\\u30d0\\u30a8
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• \\u30ad\\u30cd\\u30c8\\u30d7\\u30e9\\u30b9\\u30c8
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• \\u30ad\\u30cd\\u30c8\\u30d7\\u30e9\\u30b9\\u30c8\\u985e(kinetoplastids)
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• Benne et al., Cell (1986) \\u2026 \\u201c Major transcript of the frameshifted coxII gene from trypanosome mitochondria contains four nucleotides that are not encoded in the DNA\\u201d: RNA editing in Trypanosoma
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• Berriman et al., Science (2005)\\u2026The genome of the African trypanosome Trypanosoma brucei
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• \\u4e2d\\u5fc3\\u4f53
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• \\u5fae\\u5c0f\\u7ba1
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• \\u30db\\u30e2\\u30ed\\u30b0
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• Ogbadoyi et al., Chromosoma (2000) \\u2026 \\u201cArchitecture of the Trypanosoma brucei nucleus during interphase and mitosis\\u201d: Trypanosoma\\u306e\\u30ad\\u30cd\\u30c8\\u30b3\\u30a2\\u69d8\\u69cb\\u9020\\u3092\\u96fb\\u5b50\\u9855\\u5fae\\u93e1\\u3067\\u89b3\\u5bdf\\u3057\\u305f\\u8ad6\\u6587
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• Peacock et al., Communications Biology (2021) \\u2026 \\u201cSequential production of gametes during meiosis in trypanosomes\\u201d: trypanosoma\\u306emeiosis\\u306b\\u3064\\u3044\\u3066
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• Weir et al., eLife (2021) \\u2026 \\u201cPopulation genomics reveals the origin and asexual evolution of human infective trypanosomes\\u201d: asexual eukaryote\\u306eTrypanosoma brucei gambiense\\u306b\\u3064\\u3044\\u3066(\\u6e1b\\u6570\\u5206\\u88c2\\u304c\\u306a\\u3044\\u3068\\u3044\\u3046\\u3088\\u308a\\u306fsex\\u304c\\u306a\\u3044\\u3068\\u3044\\u3046\\u3079\\u304d\\uff1f)
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• D\\xe9jardin and Kingston. Cell (2009) \\u2026 \\u201cPurification of Proteins Associated with Specific Genomic Loci\\u201d: PICh\\u6cd5\\u306e\\u8ad6\\u6587
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• Thomas Cavalier-Smith
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• LECA \\u2026 The last eukaryotic common ancestor
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• \\u30b7\\u30b9\\u30c6\\u30e0\\u751f\\u7269\\u5b66
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• \\u53ce\\u6582\\u9032\\u5316
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• CENP-A
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• Dinoflagellate\\u2026 \\u6e26\\u97ad\\u6bdb\\u85fb
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• Dinokaryon
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• \\u7121\\u810a\\u690e\\u52d5\\u7269\\u306e\\u767a\\u751f \\u2026 \\u56e3\\u52dd\\u78e8\\u5148\\u751f\\u3089\\u8457
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• \\u30d2\\u30c9\\u30ed\\u30ad\\u30b7\\u30eb\\u30e1\\u30c1\\u30eb\\u30a6\\u30e9\\u30b7\\u30eb
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• Talbert et al., The kinetochore (2009) \\u2026 \\u201cEvolution of Centromeres and Kinetochores: A Two-Part Fugue\\u201d \\u30bb\\u30f3\\u30c8\\u30ed\\u30e1\\u30a2\\u3068\\u30ad\\u30cd\\u30c8\\u30b3\\u30a2\\u306e\\u9032\\u5316\\u306b\\u3064\\u3044\\u3066\\u306e\\u8ad6\\u6587\\u3002Henikoff lab
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• \\u30d5\\u30a1\\u30a4\\u30f3\\u30de\\u30f3
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• \\u30c7\\u30fc\\u30e2\\u30f3\\u30b3\\u30a2
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• \\u30d7\\u30eb\\u30c8\\u30cb\\u30a6\\u30e0\\u306f\\u6e29\\u304b\\u3044
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• What I cannot create, I do not understand. \\u2026 \\u81ea\\u5206\\u3067\\u4f5c\\u308c\\u306a\\u3044\\u3082\\u306e\\u306f\\u3001\\u7406\\u89e3\\u3057\\u3066\\u3044\\u306a\\u3044\\u3002
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• Synthetic biology \\u2026 \\u5408\\u6210\\u751f\\u7269\\u5b66
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• \\u30c4\\u30a4\\u30fc\\u30c81 \\u2026 EMBO, HSFP, Wellcome Trust\\u306b\\u3088\\u308b\\u30b5\\u30dd\\u30fc\\u30c8
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• KKT1 uniprot
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• Akiyoshi et al., Genes Dev. (2009) \\u2026 Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit
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• Akiyoshi et al., Nature (2010) \\u2026 Tension directly stabilizes reconstituted kinetochore-microtubule attachments
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• \\u7cbe\\u88fd\\u3057\\u305f\\u52d5\\u539f\\u4f53\\u3092\\u7528\\u3044\\u305f\\u52d5\\u539f\\u4f53\\u3068\\u30b9\\u30d4\\u30f3\\u30c9\\u30eb\\u5fae\\u5c0f\\u7ba1\\u3068\\u306e\\u7d50\\u5408\\u306e\\u518d\\u69cb\\u6210 \\u2026 \\u65b0\\u7740\\u8ad6\\u6587\\u30ec\\u30d3\\u30e5\\u30fc\\u3002\\u79cb\\u5409\\u3055\\u3093\\u306e\\u535a\\u58eb\\u6642\\u4ee3\\u306e\\u8ad6\\u6587\\u89e3\\u8aac
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• \\u30c8\\u30ea\\u30d1\\u30ce\\u30bd\\u30fc\\u30de\\u306e\\u3082\\u3064\\u578b\\u7834\\u308a\\u306a\\u52d5\\u539f\\u4f53\\u30bf\\u30f3\\u30d1\\u30af\\u8cea\\u306e\\u767a\\u898b \\u2026 \\u65b0\\u7740\\u8ad6\\u6587\\u30ec\\u30d3\\u30e5\\u30fc\\u3002\\u30c8\\u30ea\\u30d1\\u30ce\\u30bd\\u30fc\\u30de\\u306e\\u30ad\\u30cd\\u30c8\\u30b3\\u30a2\\u8ad6\\u6587\\u306e\\u65e5\\u672c\\u8a9e\\u89e3\\u8aac
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• Sue Biggins
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• Sue Biggins\\u5148\\u751f\\u306e\\u30a4\\u30f3\\u30bf\\u30d3\\u30e5\\u30fc
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• Sue Biggins\\u5148\\u751f\\u306eiBiology
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• \\u30c9\\u30d6\\u30b8\\u30e3\\u30f3\\u30b9\\u30ad\\u30fc
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• \\u9ad8\\u4e95\\u7814
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• 44. Tabasheer (researchat.fm) \\u2026 \\u4f0a\\u85e4\\u7be4\\u592a\\u90ce\\u3001\\u5357\\u65b9\\u718a\\u6960\\u3092\\u542b\\u3080\\u30011800\\u5e74\\u4ee3\\u5f8c\\u534a\\u3001Nature\\u306b\\u6295\\u7a3f\\u3057\\u305f\\u65e5\\u672c\\u4eba\\u7814\\u7a76\\u8005\\u306b\\u3064\\u3044\\u3066\\u8a71\\u3057\\u307e\\u3057\\u305f\\u3002
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Editorial notes

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• \\u6b21\\u306e\\u30b7\\u30ea\\u30fc\\u30ba\\u306b\\u3082\\u671f\\u5f85\\u3057\\u305f\\u3044\\u3067\\u3059 (soh)
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• \\u8a71\\u3057\\u59cb\\u3081\\u3067\\u69cb\\u60f3\\u304b\\u3089\\u306f\\u305a\\u308c\\u3066\\u3057\\u307e\\u3063\\u305f\\u305f\\u3081\\u3001\\u30a2\\u30ef\\u30a2\\u30ef\\u3057\\u3066\\u3057\\u307e\\u3044\\u307e\\u3057\\u305f\\u3002\\u8272\\u3005\\u3068\\u3063\\u3061\\u3089\\u304b\\u3063\\u3066\\u3059\\u3044\\u307e\\u305b\\u3093\\u3067\\u3057\\u305f\\u3002\\u6b21\\u56de\\u30c1\\u30e3\\u30f3\\u30b9\\u304c\\u3042\\u308c\\u3070\\u3082\\u3046\\u5c11\\u3057\\u307e\\u3068\\u3081\\u3089\\u308c\\u308b\\u3088\\u3046\\u304c\\u3093\\u3070\\u308a\\u307e\\u3059\\u3002(tadasu)
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• \\u30ad\\u30cd\\u30c8\\u30b3\\u30a2\\u3063\\u3066\\u540d\\u524d\\u304b\\u3063\\u3053\\u3044\\u3044(coela)
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