Published: Dec. 28, 2018, 5:34 p.m.
Here is a summary of this episode:
- In patients with liver impairment, it is better to use drugs that are metabolized by phase II enzymes or drugs that are not metabolized by the liver at all.
- Patients with severe renal impairment may also have liver impairment. Use ⅔ of the recommended dose.
- Benzodiazepines and Z-drugs are contraindicated in CO2 retainers and those with severe sleep apnea. Opiates are better than benzodiazepines in patients with terminal breathlessness.