After completing the material in this chapter each student should:- * understand the separate assumptions associated with the one compartment model, rapid IV bolus dosing and linear elimination * understand the properties of first order kinetics, linear models * be able to write the differential equations for a simple pharmacokinetic model * be able to define, use, and calculate the parameters: * * kel (elimination rate constant) * * V (apparent volume of distribution) * * t1/2 (half-life) * * AUC (area under the concentration versus time curve) * * Cl (clearance) as they apply to a one compartment linear model * be able to use the integrated equations for a one compartment linear model to perform various dose and dosing regminen calculations