After completing the material in this chapter each student should:- * understand and be able to describe drug accumulation after repeated dose administration * be able to use the integrated equations for drug concentration after multiple IV bolus doses * be able to calculate suitable dosing regimens including loading dose, maintenance dose, and dosing interval * be able to define, use, and calculate the parameters: * * dosing interval, τ * * accumulation factor, R * * maximum plasma concentration, Cpmax * * minimum plasma concentration, Cpmin * be able to calculate suitable multiple dose regimen to achieve desired Cpmin and Cpmax values