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This session will address systems solutions to short-term mission (STM) drug-related quality of care problems. The quality of care various STM systems are capable of providing varies tremendously: Well designed STM systems enable physicians, pharmacists and other providers to deliver high quality care and have the greatest possible impact for patient health and for the Kingdom; Inadequately designed STM systems provide poor quality care and often cause more harm than benefit regardless of the training and expertise of team leaders and providers. We will assess mistakes made and lessons learned on over 45 global STMs, as well as 15 years long-term missions clinic practice in an area frequented by STMs. STM systems based on the work of missionary mentors, Jesus’ teaching and evidence based guidelines will also be reviewed.