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b'In this episode, I explain the biology, symptoms, causes and types of bipolar disorder (sometimes called bipolar depression). I discuss neuroplasticity and how the brain normally regulates mood, energy, and perceptions; then, I contrast that with the biology of bipolar disorder, which is characterized by extremes of energy and mood, e.g., mania and depression. I outline the mechanisms through which bipolar disorder manifests in the brain, including deficits of interoception and reduced connections between the parietal and limbic systems. I also outline how treatment options (such as lithium) work in part through homeostatic plasticity.\\u2019 I discuss not only lithium but also the treatment of bipolar with ketamine, different talk therapies, electroconvulsive therapy, transcranial magnetic stimulation, and nutraceuticals, including Omega-3 and Inositol supplementation. This episode should interest anyone who has or knows someone with bipolar disorder and, more broadly, those interested in how the brain works to create a balance between thoughts, energy levels, focus, and mood.\\nFor the full show notes, visit hubermanlab.com.\\nThank you to our sponsors\\nAG1 (Athletic Greens): https://athleticgreens.com/huberman\\nLMNT: https://drinklmnt.com/huberman\\nSupplements from Momentous\\nhttps://www.livemomentous.com/huberman\\nTimestamps\\n(00:00:00) Bipolar Disorder\\n(00:03:42) Tool: Appetite Suppression & GLP-1, Parallel Pathways, Yerba Mate\\n(00:9:19) Sponsors: AG1, LMNT\\n(00:14:24) Prevalence & Severity of Bipolar Disorder\\n(00:16:30) Bipolar Disorder I, Diagnostic Criteria of Mania\\n(00:28:58) Bipolar Disorder II, Individual Variability\\n(00:33:07) Bipolar I vs. Bipolar II: Manic, Depressive & Symptom-Free States\\n(00:38:20) Consequences of Bipolar Disorder, Heritability\\n(00:46:53) Bipolar Disorder vs. Borderline Personality Disorder\\n(00:51:51) Mania & Depression, Negative Impacts\\n(00:53:06) History of Lithium Treatment\\n(01:02:44) Lithium Treatment & Side-Effects\\n(01:05:05) Effects of Lithium: BDNF, Anti-inflammatory & Neuroprotection\\n(01:10:10) Neural Circuits of Bipolar Disorder, Interoception, Hyper- vs. Hypoactivity\\n(01:17:11) Neural States & Mania, Parietal Lobe & Limbic System\\n(01:22:58) Homeostatic Plasticity, Synaptic Scaling, Lithium & Ketamine\\n(01:36:00) Talk Therapies: Cognitive Behavioral Therapy, Family-Focused Therapy, Interpersonal & Social Rhythm Therapy\\n(01:43:18) Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (rTMS)\\n(01:48:01) Psylocibin, Cannabis\\n(01:51:50) Lifestyle Support, Supplements: Inositol & Omega-3 Fatty Acids\\n(02:03:31) Omega-3s, Membrane Fluidity & Neuroplasticity\\n(02:06:44) Mania, Creativity & Occupations\\n(02:15:33) Bipolar Disorder: Diagnosis, Neural Circuits & Treatment\\n(02:17:45) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous Supplements, Instagram, Twitter, Neural Network Newsletter\\nTitle Card Photo Credit: Mike Blabac\\nDisclaimer'