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b'This episode serves as a sort of \\u201cDopamine Masterclass\\u201d. I discuss the immensely powerful chemical that we all make in our brain and body: dopamine. I describe what it does and the neural circuits involved. I explain dopamine peaks and baselines, and the cell biology of dopamine depletion. I include 14 tools for how to control your dopamine release for sake of motivation, focus, avoiding and combating addiction and depression, and I explain why dopamine stacking with chemicals and behaviors inevitably leads to states of underwhelm and poor performance. I explain how to achieve sustained increases in baseline dopamine, compounds that injure and protect dopamine neurons including caffeine from specific sources. I describe non-prescription supplements for increasing dopamine\\u2014both their benefits and risks\\u2014and synergy of pro-dopamine supplements with those that increase acetylcholine.\\xa0\\nFor the full show notes, visit hubermanlab.com.\\nThank you to our sponsors\\nAG1 (Athletic Greens): https://athleticgreens.com/huberman\\nLMNT: https://drinklmnt.com/huberman\\nSupplements from Momentous\\nhttps://www.livemomentous.com/huberman\\nTimestamps\\n(00:00:00) Introduction & Tool 1 to Induce Lasting Dopamine\\n(00:05:04) Sponsors: AG1, LMNT\\n(00:09:10) Upcoming (Zero-Cost) Neuroplasticity Seminar for Educators\\n(00:09:58) What Dopamine (Really) Does\\n(00:15:30) Two Main Neural Circuits for Dopamine\\xa0\\n(00:18:14) How Dopamine Is Released: Locally and Broadly\\n(00:22:03) Fast and Slow Effects of Dopamine\\n(00:25:03) Dopamine Neurons Co-Release Glutamate\\n(00:28:00) Your Dopamine History Really Matters\\xa0\\n(00:30:30) Parkinson\\u2019s & Drugs That Kill Dopamine Neurons. My Dopamine Experience\\xa0\\n(00:36:58) Tool 3 Controlling Dopamine Peaks & Baselines\\n(00:40:06) Chocolate, Sex (Pursuit & Behavior), Nicotine, Cocaine, Amphetamine, Exercise\\n(00:46:46) Tool 4 Caffeine Increases Dopamine Receptors\\n(00:49:54) Pursuit, Excitement & Your \\u201cDopamine Setpoint\\u201d\\n(00:56:46) Your Pleasure-Pain Balance & Defining \\u201cPain\\u201d\\n(01:00:00) Addiction, Dopamine Depletion, & Replenishing Dopamine\\n(01:07:50) Tool 5 Ensure Your Best (Healthy) Dopamine Release\\n(01:15:28) Smart Phones: How They Alter Our Dopamine Circuits\\n(01:19:45) Stimulants & Spiking Dopamine: Counterproductive for Work, Exercise & Attention\\n(01:22:20) Caffeine Sources Matter: Yerba Mate & Dopamine Neuron Protection\\n(01:24:20) Caffeine & Neurotoxicity of MDMA\\n(01:26:15) Amphetamine, Cocaine & Detrimental Rewiring of Dopamine Circuits\\n(01:27:57) Ritalin, Adderall, (Ar)Modafinil: ADHD versus non-Prescription Uses\\n(01:28:45) Tool 6 Stimulating Long-Lasting Increases in Baseline Dopamine\\xa0\\n(01:37:55) Tool 7 Tuning Your Dopamine for Ongoing Motivation\\n(01:47:40) Tool 8 Intermittent Fasting: Effects on Dopamine\\xa0\\n(01:53:09) Validation of Your Pre-Existing Beliefs Increases Dopamine\\n(01:53:50) Tool 9 Quitting Sugar & Highly Palatable Foods: 48 Hours\\n(01:55:36) Pornography\\n(01:56:50) Wellbutrin & Depression & Anxiety\\n(01:58:30) Tool 10 Mucuna Pruriens, Prolactin, Sperm, Crash Warning\\n(02:01:45) Tool 11 L-Tyrosine: Dosages, Duration of Effects & Specificity\\n(02:05:20) Tool 12 Avoiding Melatonin Supplementation, & Avoiding Light 10pm-4am\\n(02:07:00) Tool 13 Phenylethylamine (with Alpha-GPC) For Dopamine Focus/Energy\\n(02:08:20) Tool 14 Huperzine A\\n(02:10:02) Social Connections, Oxytocin & Dopamine Release\\n(02:12:20) Direct & Indirect Effects: e.g., Maca; Synthesis & Application\\n(02:14:22) Zero-Cost & Other Ways To Support Podcast & Research\\nTitle Card Photo Credit: Mike Blabac\\nDisclaimer'