Sugar, Cancer & The Warburg Effect

Published: Feb. 27, 2023, 4:33 p.m.

Let's discuss more about cancer, sugar and The Warburg effect.\xa0

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Link to study & Images:\xa0https://youtu.be/I6_QmMuluiE

Show Notes:\xa0

0:00 Intro
0:05 Breast, lung, colon, and brain cancer have been linked with deranged cellular metabolism.\xa0
0:27 Cancer is the second leading cause of mortality in the US.\xa0
1:00 Normal cells aerobically breakdown carbohydrates and fats to create ATP.
1:50 Cancer cells, in the presence of oxygen, ferment glucose to make pyruvate and lactate.\xa0
3:10 Mitochondria regulate preprogrammed cell death.\xa0
5:10 Dysregulated glucose metabolism fosters a tumor microenvironment that favors expansive growth.\xa0
5:35 PET scan is diagnostic imaging tool which uses a radioisotope glucose, fluorodeoxyglucose, that helps to diagnose cancer.
7:00 Metformin, which decreases glucose, is being used in cancer treatment and therapeutics.
9:10 Tumors require a chronic overexpression of lactate. Exercise is a transient acute increase in lactate.
10:04 Lactate can cause a cascade of events which helps the tumor grow more blood vessels.
11:25 By circumventing mitochondria for energy, it\u2019s ability to induce apoptosis is inhibited.
13:00 Your microenvironment can foster or inhibit the growth of a tumor.
14:45 Cold immersion is a mitochondrial therapy.\xa0
15:40 There is an association with a lower risk for breast cancer, total cancers and colorectal cancers for people who follow dietary prevention guidelines.