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Are genetic therapies for sickle cell disease beginning to come of age? Claudia Hammond talks to David Williams and Erica Esrick of Boston Children\\u2019s Hospital about their promising results with a gene therapy for the disease in a pilot trial involving six young patients. Their report appears in the latest edition of the New England Journal of Medicine alongside encouraging results of a CRISPR gene editing therapy for sickle cell disease. Both approaches target the same gene \\u2013 the result of which is to make bone marrow cells to produce foetal haemoglobin to compensate for people\\u2019s faulty adult haemoglobin.

BBC Global health correspondent Naomi Grimley has a coronavirus global round up for us, and we report on the discovery of a pair of salivary glands new to medical science \\u2013 the first new set of organs to be discovered for centuries. Dutch researchers detected them with a sophisticated form of body scanning, hiding where the back of the nasal cavity meets the top of the throat. It\\u2019s an anatomical revelation which may have implications for kinder radiotherapy for head and neck cancer.

Claudia\\u2019s studio guest is Tabitha Mwangi, who is a lecturer in public health at Anglia Ruskin University and has also been a malaria researcher in Kenya. Tabitha talks about the great benefits of giving children four months of malaria prophylaxis tablets during the rainy season in West and Central sub-Sahelian Africa. A study involving millions of children and tens of thousands of health workers halved the number of children dying from malaria. Tabitha also tells Claudia about a simple strategy for improving the success rate in getting people onto TB treatment quickly, and whether schemes in low income countries to encourage mothers to grow their own vegetables to improve their children\\u2019s nutrition actually work.

Presenter: Claudia Hammond\\nProducer: Andrew Luck-Baker

(Picture: Dr. Erica Esrick and Manny Johnson, the first patient to participate in the Boston Children\\u2019s Hospital sickle cell disease clinical trial. Credit: Boston\\u2019s Children\\u2019s Hospital.)