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Morgan Levine, Ph.D., developed the phenotypic aging clock called PhenoAge and is a Founding Principal Investigator at Altos Labs, a biotech company that seeks to understand the mechanisms that drive the aging process and age-related diseases with the hope of identifying possible interventions. Additionally, Dr. Levine is an assistant professor of pathology at the Yale University School of Medicine, where her research focuses on the science of biological aging.

Dr. Levine completed a postdoctoral fellowship with previous guest Dr. Steve Horvath, a pioneer in the field of epigenetic clocks.\\xa0

In this episode, Dr. Levine and I discuss:\\xa0

• (00:00) Introduction to Dr. Morgan Levine
• (01:19)\\xa0What is aging and why does it matter to scientists?
• (04:45)\\xa0Hallmarks of aging
• (08:59)\\xa0The advantage of epigenetic clocks in research
• (19:05)\\xa0Epigenetic age acceleration
• (36:40)\\xa0Are epigenetic changes in aging a cause or consequence?
• (42:15)\\xa0Reversing epigenetic age with interrupted reprogramming techniques
• (49:27)\\xa0Therapeutic plasma exchange in aging and pro-aging factors in blood\\xa0
• (56:01)\\xa0Lifestyle factors that accelerate epigenetic age
• (01:03:23)\\xa0Reliability of consumer epigenetic aging tests
• (01:06:12)\\xa0Construct validity of epigenetic clocks
• (01:12:06)\\xa0Thoughts on most exciting research in aging field\\xa0
• (01:13:44)\\xa0Dr. Levine\'s lifestyle habits

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