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David A. Sinclair

David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal\\xa0Aging, where he serves as co-chief editor.

Dr. Sinclair\'s work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging\'s effects. In particular, he has examined the role of sirtuins in disease and aging, with special emphasis on how sirtuin activity is modulated by compounds produced by the body as well as those consumed in the diet, such as resveratrol. His work has implications for human metabolism, mitochondrial and neurological health, and cancer.

In this episode, you\'ll discover:

• (00:00)\\xa0Introduction
• (17:59)\\xa0Caloric restriction, fasting, and exercise activate sirtuin longevity genes
• (21:47)\\xa0Boosting NAD+ levels reduces sirtuin loss with age
• (23:03)\\xa0Resveratrol extends sirtuin activation\\xa0
• (27:36)\\xa0NAD+ resets epigenetic aging clocks
• (31:54)\\xa0Yamanaka factors reprogram adult cells into stem cells
• (46:48)\\xa0Resveratrol is a xenohormetic compound\\xa0
• (55:35)\\xa0Resveratrol improved cognitive function in Alzheimer\'s disease
• (58:03)\\xa0NR and NMN improve cognitive function\\xa0
• (01:06:19)\\xa0NMN delays aging in multiple organs
• (01:01:22)\\xa0 Challenges of translating animal research

If you\\u2019re interested in learning more, you can read the full show notes here.

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