#041 Dr. Charles Raison on Depression, the Immune-Brain Interface & Whole-Body Hyperthermia

Published: March 19, 2018, 8:15 p.m.

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Charles Raison

Charles Raison, M.D. is a professor at the School of Human Ecology at the University of Wisconsin-Madison and Founding Director of the Center for Compassion Studies in the College of Social and Behavioral Sciences at the University of Arizona.

Dr. Raison\\u2019s research focuses on inflammation and the development of depression in response to illness and stress. He also examines the physical and behavioral effects of compassion training on the brain, inflammatory processes, and behavior as well as the effect of heat stress as a potentially therapeutic intervention major depressive disorder.

In this episode, you\'ll discover:

  • (00:00)\\xa0Introduction
  • (06:26)\\xa0Role of inflammation in depression
  • (10:08)\\xa0Evolutionary mechanism
  • (16:19)\\xa0Genetics of depression
  • (22:57)\\xa0How obesity causes depression biochemically
  • (33:32)\\xa0Does exercise treat depression
  • (36:08)\\xa0Hyperthermia as treatment
  • (46:08)\\xa0Inflammation promotes depression
  • (53:39)\\xa0Did we evolve to need hormetic stress?
  • (01:03:38)\\xa0Heat-shock proteins
  • (01:06:10)\\xa0Repurposing ancient wisdom
  • (01:17:31)\\xa0Psychedelics and meditation
  • (01:27:51)\\xa0What is the role of conventional pharmacotherapy?
  • (01:35:19)\\xa0Lifestyle modifications for depression
  • (01:42:21)\\xa0Why light and circadian rhythm are important for mental health

If you\\u2019re interested in learning more, you can read the full show notes here.

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