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b'In this episode of the Epigenetics Podcast, we caught up with Ian Maze from Ichan School of Medicine at Mount Sinai and a Howard Hughes Medical Institute (HHMI) Investigator to talk about his work on the role of histone dopaminylation and serotinylation in neuronal plasticity.\\nThe Maze group focuses on understanding the complex interplay between chromatin regulatory mechanisms in brain and neuronal plasticity. The lab places an emphasis on psychiatric disorders associated with monoaminergic (e.g., serotonin, dopamine, etc.) dysfunction, such as major depressive disorder and drug addiction. In particular the Maze team has investigated cocaine addiction and its effect on chromatin by serotonylation and dopaminylation of Histone H3 Tails.\\n\\xa0\\nReferences\\n\\nMaze, I., Covington, H. E., Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., Ren, Y., Sampath, S. C., Hurd, Y. L., Greengard, P., Tarakhovsky, A., Schaefer, A., & Nestler, E. J. (2010). Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity. Science, 327(5962), 213\\u2013216. https://doi.org/10.1126/science.1179438\\n\\n\\nFarrelly, L. A., Thompson, R. E., Zhao, S., Lepack, A. E., Lyu, Y., Bhanu, N. V., Zhang, B., Loh, Y.-H. E., Ramakrishnan, A., Vadodaria, K. C., Heard, K. J., Erikson, G., Nakadai, T., Bastle, R. M., Lukasak, B. J., Zebroski, H., Alenina, N., Bader, M., Berton, O., \\u2026 Maze, I. (2019). Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Nature, 567(7749), 535\\u2013539. https://doi.org/10.1038/s41586-019-1024-7\\n\\n\\nLepack, A. E., Werner, C. T., Stewart, A. F., Fulton, S. L., Zhong, P., Farrelly, L. A., Smith, A. C. W., Ramakrishnan, A., Lyu, Y., Bastle, R. M., Martin, J. A., Mitra, S., O\\u2019Connor, R. M., Wang, Z.-J., Molina, H., Turecki, G., Shen, L., Yan, Z., Calipari, E. S., \\u2026 Maze, I. (2020). Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking. Science, 368(6487), 197\\u2013201. https://doi.org/10.1126/science.aaw8806\\n\\xa0\\n\\nRelated Episodes\\n\\nDevelopment of Integrative Machine Learning Tools for Neurodegenerative Diseases (Enrico Glaab)\\n\\n\\nEpigenetic Influence on Memory Formation and Inheritance (Isabelle Mansuy)\\n\\n\\nCpG Islands, DNA Methylation, and Disease (Sir Adrian Bird)\\n\\n\\xa0\\nContact\\n\\nActive Motif on Twitter\\n\\n\\nEpigenetics Podcast on Twitter\\n\\n\\nActive Motif on LinkedIn\\n\\n\\nActive Motif on Facebook\\n\\n\\nEmail: podcast@activemotif.com'