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b'In this episode of the Epigenetics Podcast, we caught up with Katja Kobow from the Universit\\xe4tsklinikum Erlangen to talk about her work on the role of DNA methylation in Epilepsy.\\nKatja Kobow started studying the role of Epigenetics in Epilepsy by doing a genome wide Bisulfite-Sequencing screen that revealed a typical DNA methylation signature of epileptic patients versus healthy controls. After these initial results in human patient samples, she switched to an animal model to investigate this further. Now the focus of the Kobow Lab is to look for the same DNA methylation signature in blood samples, using this as a basis for the development of a potential prognostic marker for Epilepsy.\\n\\xa0\\nReferences\\n\\nJablonski, Janos, Lucas Hoffmann, Ingmar Bl\\xfcmcke, Anna Fejtov\\xe1, Steffen Uebe, Arif B. Ekici, Vadym Gnatkovsky, and Katja Kobow. 2021. \\u201cExperimental Epileptogenesis in a Cell Culture Model of Primary Neurons from Rat Brain: A Temporal Multi-Scale Study.\\u201d Cells 10(11):3004. doi: 10.3390/cells10113004.\\n\\n\\nJablonski, Janos, Lucas Hoffmann, Ingmar Bl\\xfcmcke, Anna Fejtov\\xe1, Steffen Uebe, Arif B. Ekici, Vadym Gnatkovsky, and Katja Kobow. 2021. \\u201cExperimental Epileptogenesis in a Cell Culture Model of Primary Neurons from Rat Brain: A Temporal Multi-Scale Study.\\u201d Cells 10(11):3004. doi: 10.3390/cells10113004.\\n\\n\\nKobow, Katja, Mark Ziemann, Harikrishnan Kaipananickal, Ishant Khurana, Angelika M\\xfchlebner, Martha Feucht, Johannes A. Hainfellner, Thomas Czech, Eleonora Aronica, Tom Pieper, Hans Holthausen, Manfred Kudernatsch, Hajo Hamer, Burkhard S. Kasper, Karl R\\xf6ssler, Valerio Conti, Renzo Guerrini, Roland Coras, Ingmar Bl\\xfcmcke, Assam El\\u2010Osta, and Antony Kaspi. 2019. \\u201cGenomic DNA Methylation Distinguishes Subtypes of Human Focal Cortical Dysplasia.\\u201d Epilepsia 60(6):1091\\u20131103. doi: 10.1111/epi.14934.\\n\\n\\nD\\u0119bski, Konrad J., Asla Pitkanen, Noora Puhakka, Anna M. Bot, Ishant Khurana, Kn Harikrishnan, Mark Ziemann, Antony Kaspi, Assam El-Osta, Katarzyna Lukasiuk, and Katja Kobow. 2016. \\u201cEtiology Matters \\u2013 Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy.\\u201d Scientific Reports 6(1):25668. doi: 10.1038/srep25668.\\n\\n\\nKobow, Katja, Antony Kaspi, K. N. Harikrishnan, Katharina Kiese, Mark Ziemann, Ishant Khurana, Ina Fritzsche, Jan Hauke, Eric Hahnen, Roland Coras, Angelika M\\xfchlebner, Assam El-Osta, and Ingmar Bl\\xfcmcke. 2013. \\u201cDeep Sequencing Reveals Increased DNA Methylation in Chronic Rat Epilepsy.\\u201d Acta Neuropathologica 126(5):741\\u201356. doi: 10.1007/s00401-013-1168-8.\\n\\xa0\\n\\nRelated Episodes\\n\\nCpG Islands, DNA Methylation, and Disease (Sir Adrian Bird)\\n\\n\\nEffects of DNA Methylation on Chromatin Structure and Transcription (Dirk Sch\\xfcbeler)\\n\\n\\nEffects of DNA Methylation on Diabetes (Charlotte Ling)\\n\\n\\xa0\\nContact\\n\\nActive Motif on Twitter\\n\\n\\nEpigenetics Podcast on Twitter\\n\\n\\nActive Motif on LinkedIn\\n\\n\\nActive Motif on Facebook\\n\\n\\nEmail: podcast@activemotif.com'