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b"In this episode of the Epigenetics Podcast, we caught up with Erna Magn\\xfasd\\xf3ttir from the University of Iceland to talk about her work on the role of Blimp-1 in immune-cell differentiation.\\nThe Magn\\xfasd\\xf3ttir Lab is interested in how the mammalian genome is interpreted in a context dependent manner, leading to different cellular states, by using mouse primordial germ cells as well as mouse and human B-cells as model systems. More specifically, the team is interested in the Transcription Factor Blimp-1 and its effect on immune cell differentiation. Next to its function in immune cells, Blimp-1 also plays a role in Waldenstr\\xf6m\\u2019s macroglobulinemia. The lab hopes to reveal the intricacies in disease progression and alteration in cellular states to increasingly aggressive tumor behavior.\\n\\xa0\\nReferences\\n\\nMagn\\xfasd\\xf3ttir, E., Dietmann, S., Murakami, K. et al. A tripartite transcription factor network regulates primordial germ cell specification in mice. Nat Cell Biol 15, 905\\u2013915 (2013). https://doi.org/10.1038/ncb2798\\n\\n\\nAnderson, K.J., \\xd3svaldsd\\xf3ttir, \\xc1.B., Atzinger, B. et al. The BLIMP1\\u2014EZH2 nexus in a non-Hodgkin lymphoma. Oncogene 39, 5138\\u20135151 (2020). https://doi.org/10.1038/s41388-020-1347-8\\n\\xa0\\n\\nRelated Episodes\\n\\nPioneer Transcription Factors and Their Influence on Chromatin Structure (Ken Zaret)\\n\\n\\nDNA Methylation and Mammalian Development (D\\xe9borah Bourc'his)\\n\\n\\nThe Role of SMCHD1 in Development and Disease (Marnie Blewitt)\\n\\n\\xa0\\nContact\\n\\nActive Motif on Twitter\\n\\n\\nEpigenetics Podcast on Twitter\\n\\n\\nActive Motif on LinkedIn\\n\\n\\nActive Motif on Facebook\\n\\n\\nEmail: podcast@activemotif.com"