The Effect of Vitamin D on the Epigenome (Folami Ideraabdullah)

Published: Jan. 27, 2022, 8:01 a.m.

b'In this episode of the Epigenetics Podcast, we caught up with Folami Ideraabdullah from the University of Chapel Hill to talk about her work on the environmental modulation of the epigenome during development.\\nThe lab of Folami Ideraabdullah focuses on studying how environmental factors modulate the epigenome. In particular the team investigates how Vitamin D levels influence epigenetic processes and, hence, the susceptibility for diseases like adipositas. Folami Ideraabdullah started with a genome-wide screen of DNA Methylation patterns that are observed after Vitamin D depletion. This work was then followed up by investigating the impact of Vitamin D depletion on mouse sperm DNA methylation. \\n\\xa0\\nReferences\\n\\nXue, J., Schoenrock, S. A., Valdar, W., Tarantino, L. M., & Ideraabdullah, F. Y. (2016). Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations. Clinical Epigenetics, 8(1), 107. https://doi.org/10.1186/s13148-016-0276-4\\n\\n\\nXue, J., Gharaibeh, R. Z., Pietryk, E. W., Brouwer, C., Tarantino, L. M., Valdar, W., & Ideraabdullah, F. Y. (2018). Impact of vitamin D depletion during development on mouse sperm DNA methylation. Epigenetics, 13(9), 959\\u2013974. https://doi.org/10.1080/15592294.2018.1526027\\n\\n\\nXue, J., Hutchins, E. K., Elnagheeb, M., Li, Y., Valdar, W., McRitchie, S., Sumner, S., & Ideraabdullah, F. Y. (2020). Maternal Liver Metabolic Response to Chronic Vitamin D Deficiency Is Determined by Mouse Strain Genetic Background. Current Developments in Nutrition, 4(8), nzaa106. https://doi.org/10.1093/cdn/nzaa106\\n\\xa0\\n\\nRelated Episodes\\n\\nNutriepigenetics: The Effects of Diet on Behavior (Monica Dus)\\n\\n\\nEpigenetic Influence on Memory Formation and Inheritance (Isabelle Mansuy)\\n\\n\\nEpigenetic Origins Of Heterogeneity And Disease (Andrew Pospisilik)\\n\\n\\xa0\\nContact\\n\\nActive Motif on Twitter\\n\\n\\nEpigenetics Podcast on Twitter\\n\\n\\nActive Motif on LinkedIn\\n\\n\\nActive Motif on Facebook\\n\\n\\nEmail: podcast@activemotif.com'