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b"In this episode of the Epigenetics Podcast, we caught up with Lucas Farnung from Harvard Medical School to talk about his work on the structural analysis of nucleosomes during transcription.\\nLucas Farnung started his scientific career in Patrick Cramer's lab, trying to solve the cryo-EM structure of RNA polymerase II transcribing through a nucleosome. This project spanned some time before being published in 2018, during which time Dr. Farnung accomplished several other goals. The team solved the cryo-electron microscopy structure of Chd1 from the yeast Saccharomyces cerevisiae bound to a nucleosome at a resolution of 4.8 \\xc5, solved the structure of the nucleosome-CHD4 chromatin remodeler, and investigated the structural basis of nucleosome transcription mediated by Chd1 and FACT. In 2021, he started his own lab and is now working on structural analysis of nucleosomes during transcription and how chromatin remodelers work on the chromatin template.\\nReferences\\n\\nFarnung, L., Vos, S. M., Wigge, C., & Cramer, P. (2017). Nucleosome-Chd1 structure and implications for chromatin remodelling. Nature, 550(7677), 539\\u2013542. https://doi.org/10.1038/nature24046\\n\\n\\nFarnung, L., Vos, S. M., & Cramer, P. (2018). Structure of transcribing RNA polymerase II-nucleosome complex. Nature communications, 9(1), 5432. https://doi.org/10.1038/s41467-018-07870-y\\n\\n\\nFilipovski, M., Soffers, J. H. M., Vos, S. M., & Farnung, L. (2022). Structural basis of nucleosome retention during transcription elongation. Science (New York, N.Y.), 376(6599), 1313\\u20131316. https://doi.org/10.1126/science.abo3851\\n\\xa0\\n\\nRelated Episodes\\n\\nMolecular Mechanisms of Chromatin Modifying Enzymes (Karim-Jean Armache)\\n\\n\\nRegulation of Chromatin Organization by Histone Chaperones (Genevi\\xe8ve Almouzni)\\n\\n\\nTranscription Elongation Control by the Paf1 Complex (Karen Arndt)\\n\\n\\nFrom Nucleosome Structure to Function (Karolin Luger)\\n\\n\\xa0\\n\\nContact\\n\\nEpigenetics Podcast on Twitter\\n\\n\\nEpigenetics Podcast on Instagram\\n\\n\\nEpigenetics Podcast on Mastodon\\n\\n\\nActive Motif on Twitter\\n\\n\\nActive Motif on LinkedIn\\n\\n\\nEmail: podcast@activemotif.com"