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b'In recent years it has become more and more evident, that genome folding and chromatin packaging into the nucleus plays a pivotal role in the regulation of gene expression. In this Episode of our Podcast our host Dr. Stefan Dillinger spoke with Professor Wendy Bickmore about her work on the spatial organization of the human genome. Prof. Bickmore and her team mainly use visual methods like fluorescence in situ hybridisation (FISH) to study the organization of chromosomes in human and murine cells and how they contribute to transcriptional regulation and how this organization changes during ageing, development or disease.\\nReferences \\nCharlene Boumendil, Priya Hari, \\u2026 Wendy A. Bickmore (2019) Nuclear pore density controls heterochromatin reorganization during senescence (Genes & Development) DOI: 10.1101/gad.321117.118\\xa0\\nCharlene Lema\\xeetre, Wendy A. Bickmore (2015) Chromatin at the nuclear periphery and the regulation of genome functions (Histochemistry and Cell Biology) DOI: 10.1007/s00418-015-1346-y\\xa0\\nJames Fraser, Iain Williamson, \\u2026 Jos\\xe9e Dostie (2015) An Overview of Genome Organization and How We Got There: from FISH to Hi-C (Microbiology and Molecular Biology Reviews) DOI: 10.1128/MMBR.00006-15\\xa0\\nEmmanuelle Deniaud, Wendy A Bickmore (2009) Transcription and the nuclear periphery: edge of darkness? (Current Opinion in Genetics & Development) DOI: 10.1016/j.gde.2009.01.005\\xa0\\nNicola L. Mahy, Paul E. Perry, \\u2026 Wendy A. Bickmore (2002) Spatial organization of active and inactive genes and noncoding DNA within chromosome territories (The Journal of Cell Biology) DOI: 10.1083/jcb.200111071\\nContact\\nhttps://twitter.com/activemotif \\nhttps://twitter.com/epigenetics_pod \\nhttps://www.linkedin.com/company-beta/35651/ \\nhttps://www.facebook.com/ActiveMotifInc/ \\nhttps://activemotif.com/blog \\neurotech@activemotif.com'