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b"In this episode of the Epigenetics Podcast, we caught up with Claudia Keller Valsecchi from the Institute for Molecular Biology in Mainz to talk about her work on gene dosage alterations in evolution and ageing.\\nClaudia Keller-Valsecchi's team focuses on understanding the fundamental mechanisms of how cellular function in eukaryotes is influenced by gene copy number variation. Recent findings indicate that precise MSL2-mediated gene dosage is highly relevant for organismal development. Since 2020 Claudia Keller-Valsecchi runs her own lab at the IMB in Mainz, Germany, where she tries to understand from a molecular mechanistic point of view how gene dosage compensation works, with projects in mosquitoes and in Artemia franciscanagene, as well as dosage regulation in the mammalian system regarding development and disease.\\n\\xa0\\nReferences\\n\\nKeller, C., Adaixo, R., Stunnenberg, R., Woolcock, K. J., Hiller, S., & B\\xfchler, M. (2012). HP1Swi6 Mediates the Recognition and Destruction of Heterochromatic RNA Transcripts. Molecular Cell, 47(2), 215\\u2013227. https://doi.org/10.1016/j.molcel.2012.05.009\\n\\n\\nValsecchi, C.I.K., Basilicata, M.F., Georgiev, P. et al. RNA nucleation by MSL2 induces selective X chromosome compartmentalization. Nature 589, 137\\u2013142 (2021). https://doi.org/10.1038/s41586-020-2935-z\\n\\n\\nKeller Valsecchi, C. I., Marois, E., Basilicata, M. F., Georgiev, P., & Akhtar, A. (2021). Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila. Life Science Alliance, 4(9), e202000996. https://doi.org/10.26508/lsa.202000996\\n\\xa0\\n\\nRelated Episodes\\n\\nEpigenetics and X-Inactivation (Edith Heard)\\n\\n\\nDosage Compensation in Drosophila (Asifa Akhtar)\\n\\n\\xa0\\n\\nContact\\n\\nEpigenetics Podcast on Twitter\\n\\n\\nEpigenetics Podcast on Instagram\\n\\n\\nEpigenetics Podcast on Mastodon\\n\\n\\nActive Motif on Twitter\\n\\n\\nActive Motif on LinkedIn\\n\\n\\nEmail: podcast@activemotif.com"