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b'Type 2 Diabetes (T2D) is a chronic metabolic disease, which is caused by the failure of beta-cells in the pancreas and insulin resistance in peripheral tissue and characterized by high glucose levels in the blood. World-wide 382 Million people suffer from Diabetes which makes up 8,3% of the population. Due to this high proportion it is of high interest to find a cure for this disease.\\nThe restoration of \\u03b2-cell mass and function has therefore become a field of intensive research seeking for the next generation of anti-diabetic drugs. Tremendous efforts have been made on deciphering epigenetic regulations that control metabolic tissue function. For several years, the team led by Dr. Jean-Sebastien Annicotte has dissected the molecular links between insulin producing cells, insulin target tissues and T2D/obesity development. Especially, the team research has been focused on the role of cell cycle regulators and their transcriptional co-regulators in the control of metabolic homeostasis, T2D and obesity.\\n\\xa0\\nReferences \\nJean-S\\xe9bastien Annicotte, Elisabeth Fayard, \\u2026 Johan Auwerx (2003) Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development (Molecular and Cellular Biology) DOI: 10.1128/MCB.23.19.6713-6724.2003\\xa0\\nJean-S\\xe9bastien Annicotte, Emilie Blanchet, \\u2026 Lluis Fajas (2009) The CDK4-pRB-E2F1 pathway controls insulin secretion (Nature Cell Biology) DOI: 10.1038/ncb1915\\xa0\\nEmilie Blanchet, Jean-S\\xe9bastien Annicotte, \\u2026 Lluis Fajas (2011) E2F transcription factor-1 regulates oxidative metabolism (Nature Cell Biology) DOI: 10.1038/ncb2309 \\nNabil Rabhi, Pierre-Damien Denechaud, \\u2026 Jean-S\\xe9bastien Annicotte (2016) KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response (Cell Reports) DOI: 10.1016/j.celrep.2016.03.079 \\nAlbert Giralt, Pierre-Damien Denechaud, \\u2026 Lluis Fajas (2018) E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes (Molecular Metabolism) DOI: 10.1016/j.molmet.2018.02.011\\n\\xa0\\nContact\\nhttps://twitter.com/activemotif\\nhttps://twitter.com/epigenetics_pod\\nhttps://www.linkedin.com/company-beta/35651/\\nhttps://www.facebook.com/ActiveMotifInc/\\nhttps://activemotif.com/blog\\neurotech@activemotif.com'