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From the actual documents the company submitted to the FDA and CDC.  The Pfizer-BioNTech Vaccine consists of messenger RNA wrapped up in a lipid nanoparticle package.  The RNA is formulated to avoid immune destruction once injected and to code for a CoVid spike glycoprotein that will provoke production of a human antibody.  It is stored as a frozen suspension at -112 to -76 degrees Fahrenheit.   It is supplied in a 5-7 dose vial and is given as two 30 ug IM injections 28 days apart.  The vaccine is preservative-free and contains no eggs or latex

The Pfizer vaccine was first tested for safety and immunogenicity in a phase 1 trial of 90 persons and a followup phase 2 trial of 360 persons.  It’s effectiveness was confirmed and safety checked in a randomized blinded phase 3 trial involving 38,000  participants.  

The results showed an ability to prevent any CoVid infection for all age patients of 95%, for those 18-64 yrs of 95%, and for those 65-74 was 93%, and for those 75 and older of 100%.  No severe or fatal CoVid cases occurred in those vaccinated.  Vaccine efficiency for those receiving only one dose was 52%.  

The most common adverse local reaction was injection site pain in about 80%, There was swelling of armpit lymph noses occurred in 6%.

The 3 most common systemic adverse response were fatigue lasting up to 2 days in 60%, headache in 52%, muscle aches in 37%, joint pain in 22%, chills in 35%, and fever in 15%.

Though its overall effectiveness appears to be reduced for some new CoVid strains, it almost certainly will prevent severe CoVid infections and death due to these as well as due to the original CoVid strain.   Get vaccinated!

https://www.fda.gov/media/144416/download

https://www.fda.gov/media/144245/download

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