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The psychiatric study everyone\\u2019s talking about this month is \\u201dRandomized trial of ketamine masked by surgical anesthesia in patients with depression\\u201d.

Ketamine is a dissociative drug - it produces weird drug effects like feelings of bodylessness and ego death. Recent research suggests it\\u2019s a powerful antidepressant. Usually we would try to run placebo-controlled trials. But it\\u2019s hard to run a placebo controlled trial of a dissociative. Either you feel bodylessness and ego death (in which case you know you\\u2019re getting the real drug) or you don\\u2019t (in which case you know you\\u2019re in the placebo group). Sometimes researchers try to use an \\u201cactive placebo\\u201d like midazolam - a drug that makes you feel weird and floaty. But weird and floaty feels different from bodyless and ego-dead.

https://www.astralcodexten.com/p/does-anaesthesia-prove-ketamine-placebo\\xa0