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This is an entry to the\\xa0Adversarial Collaboration Contest\\xa0by Mark Davis and Mark Webb, who sent the following introduction along with their entry:

Mark Davis is a naturopathic doctor. Naturopathic medicine is a century-old profession in the United States, but it\\u2019s small, with fewer than 10,000 NDs licensed to practice naturopathic medicine in the US in 2018. The profession has been historically highly skeptical of vaccination in general, and the modern profession is contentiously split on the topic, with vocal advocates of CDC-scheduled routine childhood vaccination and vocal dissidents both offering continuing medical education for NDs. Mark Davis\\u2019 main goal in this adversarial collaboration was to argue that there is enough reasonable doubt that routine childhood vaccines could contribute to hyper-inflammatory disease, and enough reduced harm from vaccine-preventable diseases from other medical and public health interventions (in countries with greater economic resources) that parents should be given wide latitude to make individual choices re: routine childhood vaccines despite the clear benefits to individual and public health from preventing those diseases. He became more convinced in his conversations with Mark Webb that widespread childhood vaccination is in the best interest of public health.

Mark Webb is a clinical researcher \\u2013 with a current focus in oncology. He completed a PhD in immunology, specifically focused on the mechanisms driving the development of asthma. Mark Webb\\u2019s main goal in this collaboration was to argue that atopy and autoimmunity are likely not driven by vaccination, and that this idea is a distraction from finding the real causes of the increase in these diseases. Throughout the collaboration, he was reminded of the nature of safety surveillance with all drugs, and of the sensitive nature of vaccination as a medical intervention. He became persuaded that policy should not just reflect the best evidence currently available, but should also reflect a certain degree of humility that there will always be something we don\\u2019t know.

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