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In this episode, Francisco Gonzalez-Lima, a Professor of Neuroscience and Pharmacology & Toxicology, explains the vascular hypothesis of Alzheimer\u2019s disease which says the central problem is a progressive neuronal energy crisis of impaired blood flow to the brain and impaired mitochondrial respiration. He walks us through the ways we can intervene in this process and also shares details of the exciting future of Alzheimer\u2019s treatment and prevention.

We discuss:

• Background and interest in the brain [5:15];
• The unique nature of the human brain [9:15];
• Why we\u2019ve made so little progress in Alzheimer\u2019s research [23:00];
• The amyloid beta hypothesis [28:30];
• Hypometabolism in the brain leading to cognitive decline [39:30];
• Early signs of AD, and deciphering between age-related decline versus something pathologic [47:45];
• The vascular hypothesis of Alzheimer\u2019s disease [54:00];
• The relationship between mitochondria, cytochrome c oxidase, and Alzheimer\u2019s disease [1:08:00];
• Chronic inhibition of cytochrome c oxidase leads to chronic neurodegenerative disease [1:22:45];
• Major risk factors for AD, head trauma, and other forms of dementia [1:33:45];
• Methylene blue for treating and preventing neurodegeneration [1:38:15];
• Current standard of care for AD, and the reasons for a lack of advancement [2:01:45];
• Near infrared light as a targeted treatment for cognitive decline [2:05:30];
• The ketogenic diet as a treatment and preventative measure [2:13:15];
• Exciting future research coming from Francisco [2:23:00];
• Methylene blue for traumatic brain injuries [2:25:15]; and
• More.

Learn more at\xa0www.PeterAttiaMD.com

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