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Episode Description:

Rick Johnson,\\xa0Professor of\\xa0Nephrology at the University of Colorado and\\xa0a\\xa0previous guest on The Drive, returns for a follow-up about unique features of fructose metabolism, and how this system that aided the survival of human ancestors has become potentially hazardous based on our culture\\u2019s dietary norms. In this episode, Rick explains how the body can generate fructose from glucose and how circulating glucose and salt levels can activate this conversion. He discusses the decline in metabolic flexibility associated with aging, as well as how factors such as sugar intake or menopause-associated hormone changes can alter responses to sugar across a lifetime. In addition, Rick lays out strategies for combating the development of metabolic illness using dietary changes and pharmaceutical therapies, and he discusses the impact of fructose metabolism and uric acid on kidney function and blood pressure. He concludes with a discussion of vasopressin, a hormone that facilitates fructose\\u2019s effects on weight gain and insulin resistance.

We discuss:

• Unique features of fructose metabolism and why it matters [2:45];
• A primer on fructose metabolism and uric acid [10:30];
• Endogenous fructose production, the polyol pathway, and the effect of non-fructose sugars [22:00];
• Findings from animal studies of glucose and fructose consumption [29:00];
• What\\xa0calorie-controlled\\xa0studies say about the claim that a \\u201ccalorie is a calorie\\u201d [42:15];
• Implications for aging and disease [51:15];
• Impact of endogenous\\xa0fructose\\xa0production\\xa0on obesity and metabolic syndrome [1:01:30];
• Why vulnerability to the negative effects of\\xa0sugar\\xa0increases with age and menopause [1:04:30];
• Dietary strategies to reduce the negative impact of fructose [1:16:30];
• The role of hypertension in chronic disease and tips for lowering blood pressure [1:30:45];
• The impact of fructose and uric acid on kidney function and blood pressure [1:39:45];
• The potential role of sodium in hypertension, obesity, and metabolic syndrome [1:49:00];
• The role of vasopressin in metabolic disease [1:54:00];
• More.

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