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Published: Oct. 18, 2021, 8 a.m.

In this \u201cAsk Me Anything\u201d (AMA) episode, Peter and Bob discuss all things related to testosterone: what happens when testosterone levels are low, and the potential benefits and risks of testosterone replacement therapy (TRT). They explain the physiology of testosterone, how it works, and how its level changes over the course of a person's life. They have a detailed discussion about existing literature, which reveals vast potential structural, functional, and metabolic benefits of testosterone replacement therapy. They also take a very close look at potential risks of this therapy, with a focus on the controversial effects on cardiovascular disease and prostate cancer.

If you\u2019re not a subscriber and listening on a podcast player, you\u2019ll only be able to hear a preview of the AMA. If you\u2019re a subscriber, you can now listen to this full episode on your\xa0private RSS feed\xa0or on our website at the\xa0AMA #28 show notes page. If you are not a subscriber, you can learn more about the subscriber benefits\xa0here.

We discuss:

• A primer on the\xa0hormone\xa0testosterone and how it influences gene\xa0expression\xa0[3:30];
  
• How the body naturally regulates testosterone levels [11:30];
  
• The defining threshold for "low testosterone,"\xa0how low T impacts men, and why free testosterone is the most important metric [16:15];
  
• When it makes sense to treat low testosterone [26:00];
  
• The structural and metabolic benefits of testosterone replacement therapy [29:15];
  
• Body composition changes with\xa0TRT\xa0[45:30];
  
• Changes in bone mineral density with\xa0TRT\xa0[48:15];
  
• The metabolic impact of\xa0TRT: glucose, insulin, triglycerides, and more [52:30];
  
• A\xa0study\xa0investigating\xa0testosterone replacement therapy\xa0for prevention or reversal of\xa0type 2 diabetes [59:30];
  
• The impact of TRT on metabolic parameters and body composition\u2014A study comparing results from continuous vs. interrupted treatment [1:07:15]
• The controversy over\xa0TRT\xa0and cardiovascular disease [1:21:45];
  
• Two flawed studies that shaped perceptions of\xa0risks associated with\xa0TRT\xa0[1:44:15];
  
• The controversy over\xa0TRT\xa0and prostate cancer [1:56:45];
  
• Other potential risks with testosterone replacement therapy [2:02:15]; and
  
• More

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Show notes page for this episode: https://peterattiamd.com/ama28/\xa0
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