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Hussein Yassine is a physician and researcher who studies brain lipid utilization in the context of finding preventative measures for cognitive impairment, specifically Alzheimer\u2019s disease (AD). In my conversation with Hussein, we begin with a fundamental coursework in brain biology\u2014including its architecture and energy systems. We go on to discuss what these systems look like when something goes wrong and cognitive decline ensues. We talk about the evolutionary origins of the ApoE genotype, with specific attention to the ApoE4 allele and its association with AD. We spend time discussing ApoE4 implications for the brain\u2019s fuel utilization, notably omega-3 fatty acids: EPA and DHA. We briefly pivot to the implications of recent omega-3 trials for cardiovascular disease and return to what we currently understand about EPA/DHA and brain health; we contemplate potential dietary interventions across the lifespan to preserve and prolong cognitive function.

We discuss:

• Hussein\u2019s Background and introduction to brain composition (3:00);
• The blood-brain barrier and brain filtration (8:00);
• Lipids and brain function (13:00);
• How the brain utilizes energy (18:00);
• Apolipoprotein E (ApoE) structure and function in the periphery (27:30);
• ApoE function in the brain (38:15);
• Evolutionary origins of ApoE isoforms (43:45);
• ApoE4 variant and Alzheimer\u2019s disease (AD) risk (53:30);
• Dietary fuel preference with the ApoE4 allele (1:03:00);
• The role of omega-3 fatty acids in the brain (1:13:30);
• Comparing findings from the REDUCE-IT and STRENGTH trial (1:21:45):
• The relationship between dietary omega-3 intake and brain health (1:34:15);
• Preventing cognitive decline: A critical window for DHA in ApoE4 carriers? (1:42:30);
• Hussein\u2019s ongoing research and recommendations for E4 carriers (1:54:00); and
• More.

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