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Peter is joined by writer, director, actress, and founder of HFC, Lauren Miller Rogen, and previous podcast guest and director of the Alzheimer\u2019s Prevention Clinic at Weill Cornell Medicine and New York-Presbyterian, Dr. Richard Isaacson. In this episode, Lauren tells the heartbreaking story of watching members of her family succumb to Alzheimer\u2019s disease (AD) which motivated her to proactively address her own risk with Richard\u2019s guidance. Richard discusses the various genetic and lifestyle factors that influence the risk of AD and uses Lauren\u2019s unique situation to explain how he diagnoses patients and personalizes care. They go through Lauren\u2019s protocol of preventative measures that have already produced marked results, and end with the uplifting message that one\u2019s genetic predisposition does not seal one's fate.

We discuss:

• Lauren\u2019s deep family history of Alzheimer\u2019s disease (3:10);
• The influence of genetics, epigenetics, and lifestyle on Alzheimer\u2019s disease risk (13:45);
• Lauren\u2019s mother\u2019s disease progression and the enormous stress it causes for family members (24:30);
• The various manifestations of Alzheimer\u2019s disease depending on the location of pathology (29:30);
• The three stages of Alzheimer's disease (34:45);
• Richard\u2019s deep exploration into Lauren\u2019s family history revealing clues about a diagnosis and a roadmap to successful disease mitigation (39:15);
• How exercise reduces Alzheimer\u2019s disease risk, and the different risk between males and females (58:00);
• Why knowing your APOE status is important, and whether certain people should be\xa0wearier\xa0of head trauma (1:08:00);
• How Richard uses genetic testing to personalize care (1:14:45);
• The \u201cABCs\u201d of Alzheimer\u2019s prevention, lifestyle interventions, and Lauren\u2019s personal protocol for reducing her risk (1:21:45);
• Unique treatment for people with the ApoE4 variant (1:36:30);
• Richard\u2019s mixed opinion on CBD and THC as a tool for disease prevention (1:40:00);
• Cognitive testing procedures, and how Lauren\u2019s tests furthered her commitment to her disease prevention protocol (1:41:45);
• The relevance of sense of smell and hearing in Alzheimer\u2019s disease risk and prevention (1:50:00);
• The emotional benefit of knowing you have control over your mental and physical health (1:57:30);
• HFC\u2014a charitable organization founded by Lauren and Seth (2:00:15); and
• More.

Learn more:\xa0https://peterattiamd.com/

Show notes page for this episode: https://peterattiamd.com/laurenmillerrogen-richardisaacson/\xa0

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