#111 - AMA #14: What lab tests can (and cannot) inform us about our overall objective of longevity

Published: May 18, 2020, 9:30 a.m.

In this \u201cAsk Me Anything\u201d (AMA) episode, Peter explains his framework for understanding what lab tests can (and cannot) inform us as it pertains to overall longevity, with a specific focus on atherosclerosis, cancer, Alzheimer\u2019s disease, and the physical body. Additionally, Peter shares details into two patient case studies around cardiovascular disease, including how the lab results influenced his diagnosis and treatment plan for the patients. Once again, Bob Kaplan, Peter\u2019s head of research, will be asking the questions. If you\u2019re not a subscriber and listening on a podcast player, you\u2019ll only be able to hear a preview of the AMA.\xa0If you\u2019re a subscriber, you can now listen to this full episode on your\xa0private RSS feed\xa0or on our website at the\xa0AMA #14 show notes page.

We discuss:

  • Important lab tests and reference ranges [2:35];
  • How lab testing fits into the overall objective of longevity [4:25];
  • A healthcare system set up to react to a disease rather than prevent it [8:00];
  • The four pillars of chronic disease, and the three components of healthspan [14:30];
  • Atherosclerosis\u2014How much can labs tell us about risk? [18:00];
  • Coronary calcium score (CAC)\u2014Interpreting results based on your age [24:15];
  • Cancer\u2014What lab work can tell you, and the future of liquid biopsies [28:00];
  • Alzheimer\u2019s disease\u2014What\u2019s driving Alzheimer\u2019s disease, and what labs can tell you about your risk [33:15];
  • Healthspan and the physical body\u2014Where lab testing fits, the endocrine system, and zone 2 testing [39:00];
  • Summarizing the usefulness of lab testing\u2014Where it gives great, reasonable, or lousy insight [43:15];
  • Patient case study\u2014Elevated Lp(a): Understanding ApoB, and how cholesterol levels get reduced [45:30];
  • Patient case study\u2014Familial hypercholesterolemia [59:30];
  • Coming up on a future AMA [1:10:30]; and
  • More.

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