BROADCASTS.com

b'

In this episode, my good friend David Sabatini delves into his extensive work with the mechanistic target of rapamycin\\u2014better known as mTOR\\u2014and rapamycin. The compound rapamycin is the only known pharmacological agent to extend lifespan all the way from yeast to mammals\\u2014across a billion years of evolution. David, a professor of biology and a member of the Whitehead Institute at MIT, shares his remarkable journey and discovery of mTOR in mammalian cells and its central role in nutrient sensing and longevity. Fasting, rapamycin, mTOR, autophagy, gedankenexperiments: having this conversation with David is like being the proverbial kid in the world\\u2019s greatest candy store.

We discuss:

• mTOR and David\\u2019s student years [4:30];
• Rapamycin and the discovery of mTOR [8:15];
• The connection between rapamycin, mTOR, and longevity [30:30];
• mTOR as the cell\\u2019s general contractor [34:45];
• The effect of glucose, insulin, and amino acids on mTORC1 [42:50];
• Methionine sensing and restriction [49:45];
• An intermittent approach to rapamycin [54:30];
• Rapamycin\\u2019s effects on cancer, cardiovascular disease, and neurodegeneration [57:00];
• Gedankenexperiment: couch potatoes on rapamycin vs perfectly behaved humans [1:03:15];
• David\\u2019s dream experiment with no resource constraints [1:07:00]; and
• More.

Learn more at\\xa0www.PeterAttiaMD.com

Connect with Peter on Facebook | Twitter | Instagram.