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b'Poisoning deaths are now the leading cause of unintentional deaths in the United States, says Upstate toxicologist Poisoning deaths are now the leading cause of unintentional deaths in the United States, says Upstate toxicologist Jeanna Marraffa. Jeanna Marraffa. Many of those deaths involve opioids, prescription pain medications that patients may mix with alcohol or other medications without realizing the dangers. Marraffa discusses the epidemic of opioid abuse, how it began, how it became so deadly and what withdrawal is like. Many of those deaths involve opioids, prescription pain medications that patients may mix with alcohol or other medications without realizing the dangers. Marraffa discusses the epidemic of opioid abuse, how it began, how it became so deadly and what withdrawal is like.'