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View the Show Notes For This Episode\nGet Free Weekly Health Tips from Dr. Hyman\nSign Up for Dr. Hyman\u2019s Weekly Longevity Journal\nGet Ad-free Episodes & Dr. Hyman+ Audio Exclusives\nDr. Nir Barzilai is a geroscientist, Chaired Professor of Medicine and Genetics, and the founder and principal investigator of the Einstein Nathan Shock Center and the Glenn Center for Excellence in Biology of Aging. He also studies families of centenarians that have provided genetic and biological insights on the protection against aging\u2014with several drugs developed based, in part, on these paradigm-changing studies. He is also leading the TAME (Targeting/Taming Aging with Metformin) trial to prove to the FDA that aging can be delayed and to allow for next-generation interventions.\xa0\nThis episode is brought to you by Sunlighten, Cozy Earth, BiOptimizers, and Fatty 15.\nFor a limited time, you can save up to $600 on a Sunlighten infrared sauna. Just go to sunlighten.com/mark-hyman and mention my name.\nRight now, you can save 40% when you upgrade to Cozy Earth sheets. Just head over to CozyEarth.com and use code DRHYMAN.\nTackle an overlooked root cause of stress with Magnesium Breakthrough. Visit bioptimizers.com/hyman and use code HYMAN10 to save 10% and get a free gift with purchase.\nFatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 10% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started.\nIn this episode we discuss (audio version / Apple Subscriber version):\n\nThe hallmarks of aging (9:01 / 7:10)\n\nWhat causes the hallmarks of aging? (15:40 / 13:49)\n\nDr. Barzilai\u2019s research on centenarians (23:16 / 21:25)\n\nWhy living to 100+ years is good for the economy (24:54 / 23:03)\n\nWhat enables someone to live to 100 years old? (29:30 / 25:20)\n\nTaking growth hormone and Metformin have different effects based on your age (36:58 / 32:48)\n\nThe connection between HDL cholesterol and longevity (43:36 / 39:26)\n\nDr. Barzilai\u2019s research on Metformin (56:23 / 52:13)\n\nHow Metformin works in the body and on muscle growth (1:04:51 / 1:00:41)\n\nDr. Barzilai\u2019s personal longevity (1:42:05 / 1:37:55)\n\n\nLearn more about the Longevity Genes Project and the TAME Trial.\xa0\nGet a copy of Age Later: Health Span, Life Span, and the New Science of Longevity\n\n \nLearn more about your ad choices. Visit megaphone.fm/adchoices