BROADCASTS.com

This episode is brought to you by Cozy Earth, InisdeTracker, and Rupa Health.\nIf you or a loved one struggle with addiction, this is an episode you\u2019re going to want to listen to. Many of our current pharmaceuticals stem from compounds discovered in plant medicines. And many beneficial plants that were discovered decades ago still have huge potential for changing modern medicine\u2014ibogaine is one of them. Today on The Doctor\u2019s Farmacy, I\u2019m excited to sit down with Dr. Deborah Mash to discuss the use of the African plant ibogaine and its metabolite, noribogaine, in the treatment of addiction and how it could impact the devastating opioid epidemic.\xa0\nDr. Deborah Mash is one of the world's foremost experts on ibogaine. She is the CEO and Founder of DemeRx Inc., a clinical-stage drug development company advancing ibogaine and its active metabolite noribogaine for the treatment of opioid use disorder. DemeRx has partnered with ATAI Life Sciences\u2014a global biotech platform with a special focus on psychedelic medicine\u2014to develop ibogaine for those suffering from opioid use disorder. Building on the extensive human data available around ibogaine, DemeRx and ATAI are conducting a Clinical Phase I/II trial in opioid-dependent patients. This landmark trial will advance screening procedures, dosing guidelines, and best practices for opioid withdrawal management and relapse prevention.\xa0\xa0\nThis episode is brought to you by Cozy Earth, InisdeTracker, and Rupa Health.\nCozy Earth makes the most comfortable, temperature-regulating, and nontoxic sheets on the market. Right now, get 40% off your Cozy Earth sheets. Just head over to cozyearth.com and use code MARK40.\nInsideTracker is a personalized health and wellness platform like no other. Right now they\u2019re offering my community 20% off at insidetracker.com/drhyman.\nRupa Health is a place where Functional Medicine practitioners can access more than 2,000 specialty lab tests from over 20 labs like DUTCH, Vibrant America, Genova, and Great Plains. You can check out a free, live demo with a Q&A or create an account at RupaHealth.com.\nHere are more details from our interview (audio version / Apple Subscriber version):\n\nThe long history of ibogaine\u2019s ethnobotanical and ethnopharmacological use (7:01 / 4:10)\xa0\n\nThe power of ibogaine to reset opioid tolerance and bypass many withdrawal symptoms in a single dose (15:41 / 8:11)\xa0\n\nHow ibogaine works (20:59 / 14:15)\xa0\n\nUsing ibogaine to protect against future relapse (26:09 / 19:25)\xa0\n\nEfforts to understand the importance of ibogaine\u2019s psychedelic effects (30:05 / 24:54)\xa0\n\nAssessing the success rates of recovery and relapse prevention from ibogaine treatment (37:49 / 34:02)\xa0\n\nUnderstanding the underlying drivers of addiction for better recovery and relapse treatment (41:46 / 37:55)\xa0\n\nThe concept of \u201cpsychoplastogens\u201d and turning on synaptic plasticity in the brain (51:44 / 47:52)\xa0\n\nHumanity\u2019s relationship to plants and plant medicines (57:25 /\xa0 53:34)\xa0\n\nRisks associated with and considerations for seeking ibogaine treatment (1:03:24 / 59:37)\n\n\nLearn more about Dr. Mash\u2019s work at demerx.com.\n\n \nLearn more about your ad choices. Visit megaphone.fm/adchoices