Podcasts Health & Fitness Medicine The Curbsiders Internal Medicine Podcast #9: C diff, and fecal transplants

#9: C diff, and fecal transplants

Published: July 8, 2016, 2:41 a.m.

Treat C. diff, choose\xa0the correct antibiotic regimen, and identify who needs fecal transplant\xa0as we \u201ccurbside\u201d Gastroenterologist, Dr. Adam Ehrlich from Temple University Hospital. On the show, we cover the ins-and-outs of procuring, preparing and performing transplants as well as future directions in this burgeoning field e.g. IBD, obesity, metabolic syndrome and more.

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Take Home Points:

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  1. Clostridium difficile infection is the only indication for which FMT is allowed by the FDA without special authorization
  2. FMT is VERY effective in these C difficile patients compared to standard of care (approximately 90% cure vs 30%)
  3. We are just beginning to understand the role of the microbiome in human health, and I anticipate many changes in the years ahead where modifying the microbiome will be used to help treat a number of diseases.
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\xa0Links from the Show:

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Recommended reading...

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NEJM Journal Watch for Gastroenterology - register here

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Review on novel uses for fecal transplantation

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Rossen NG, et al. Fecal microbiota transplantation as novel therapy in gastroenterology: A systematic review. World J Gastroenterol. 2015 May 7;21(17):5359-71. doi: 10.3748/wjg.v21.i17.5359.

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Randomized controlled trial of fresh vs frozen fecal transplantation

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Fresh vs Frozen Fecal Microbiota Transplant for C diff Recurrent C difficile infection. JAMA 2016

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Review on mechanisms for gut microbiota on metabolic syndromes

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Qian LL, et al. Effect of the Gut Microbiota on Obesity and Its Underlying Mechanisms: an Update. Biomed Environ Sci. 2015 Nov;28(11):839-47. doi: 10.3967/bes2015.117.