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SynTalk thinks about the key conditions that characterize and create \u2018biological\u2019 life while constantly wondering whether life is a random accident, and if we are alone in the universe (because of a singularity?). What is the future of life? How aliens (if any) are also likely to be carbon and water based, but could be completely different morphologically and functionally. How was the first cell formed, and is this one of the biggest open questions today? The continuing journey after the big bang from the physical to astrophysical to chemical to biological to social evolution (across all species via, say, pollination) way into the distant future. The concepts are derived off / from Darwin, Crick, Watson, Hoyle, Prigogine, Manfred Eigen, Delbruck, Maturana, & Stuart Kauffman, among others. Is it possible to create synthetic life in a laboratory, and does the clue to this possibility lie in the (chemical?) nature of a virus? How does speciation happen? The core significance of the cell being a \u2018phase separated structure\u2019 with organizational closure. Is the cell the unity of life? How we do \u2018not\u2019 really know where biology ends and chemistry begins. Is life a physical state (just as liquid is a state of water)? The definition of life via replication (DNA, tRNA), metabolism (metabolic charts, glucose) and energy transduction. We discuss the role of glucose as a key molecule for all life, and wonder what it is like for glucose (& other bio molecules) to be \u2018outside\u2019 life. How does self organization arise in both physical and biological systems, and how (for example) phospholipids (with hydrophobic tails and hydrophilic heads) organize itself in water? How affinities can emerge between two DNA strands. How life is a dialogical state, and neither the physical equilibrium (oxidized state like carbon dioxide) nor the state of chemical death (\u2018petroleum state\u2019). How virus \u2018lives\u2019 on the border of life and non-life. How all living stems can be characterized using unique chemistry, biochemistry, structure, & function. Why life originated from water? What is the role of weak bonds (in, say, the colloidal state of protoplasm)? How does \u2018conscious cognition\u2019 arise in living systems, & what are the links with \u2018emancipated reflexive motor actions\u2019, microtubules, dance, lizard, play, & consciousness (Mind from Matter). How does a living system talk to itself (why does a child suck its thumb)? How the feeling of \u2018free will\u2019 gives an (illusory) advantage. How life has multiple answers, and an inherent capability to change. How life is an expression of abundance. How a bio molecule is not like a sphere. The future with artificial life, cognitive robotics, & \u2018languages in nature\u2019 (of animals & languages). Why we can\u2019t wear a full body armour anymore? The SynTalkrs are: Dr. Pushpa M. Bhargava (molecular biology, CCMB, Hyderabad), Prof. Nagarjuna G. (philosophy of science, HBCSE, Mumbai)