Podcasts Health Pushing The Limits Using Peptides to Boost Your Health and Well-Being with Brian Graham

Using Peptides to Boost Your Health and Well-Being with Brian Graham

Published: March 31, 2022, 7 p.m.

Whichever stage of life you might be in, you\u2019ll want to live it to the fullest. You\u2019ll want mental clarity to perform at your best, energy to spend time with your loved ones, and a strong metabolism to maintain your ideal body weight. Using peptides is a great and effective way to remain healthy so you can make the most out of your life.

In this episode, Brian Graham discusses the functions and benefits of different peptides. He also shares some exciting developments in the peptide space. Peptides come with amazing effects \u2014 but they can also come with unpleasant side effects when not used with caution.

If you want to learn more about how peptides can power your body and enhance your quality of life, then this episode is for you!

Here are three reasons why you should listen to the full episode:
  1. Learn how peptides work on your body.
  2. Discover the latest developments in the peptide space.
  3. Find out the numerous benefits of peptides.
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Episode Highlights [04:20] Entering The Peptide Space
  • Brian is a peptide specialist at Boulder Longevity Institute.
  • When he first entered the peptide space, he worked more on performance optimization.
  • He underwent educational training at the American Academy for Anti-Aging and Regenerative Medicine and earned a formal certification.
  • He met Dr. Yurth while she was working at an orthopedic practice. They focused on bringing medical innovation to clinical relevance through collaboration.
[06:48] What Are Peptides?
  • Peptides have been around for some time, even in traditional medicine.
  • They are naturally-occurring products that help regulate or stimulate a given process. For example, insulin is a peptide that regulates blood glucose to prevent neuropathic pain and other complications.
  • Many things can be targeted on a cellular level with a given peptide.
[09:07] Proteins vs. Peptides
  • A protein that\u2019s a large peptide has more binding sites or activity.
  • Smaller sequences of amino acids become more specific for a given cellular target.
  • When chopped up, large proteins are basically made up of peptides.
  • Many environmental factors inhibit your body\u2019s ability to make a given peptide, such as prioritization and accumulation of stressors.
  • The aging process is associated with a decreased ability to make certain peptides.
[12:05] BPC-157
  • BPC-157 is a gastric-derived peptide that naturally occurs in the digestive system and helps support the cells and makeup of the digestive system.
  • It increases blood flow, thus helping modulate healing and recovery processes, especially in the musculoskeletal system.
  • It also helps with neuron regeneration and improves the integrity of the blood-brain barrier.
  • It\u2019s an F-actin sequestering peptide that dampens the effects of scarring.
[17:00] What\u2019s Happening in the Peptide Space
  • The peptide space is incredibly dynamic with lots of innovative research and people working hard to get it to clinical relevance.
  • While much of it is on the bench, there are many strides in the peptide space.
  • There are many factors affecting the accessibility of peptides, such as market exclusivity.
[19:42] Increasing Accessibility
  • Brian has been advocating and informing his patients of what\u2019s available to them and gives them access if possible.
  • Peptides that are in clinical development and have gone through safety trials require an API.
  • Unfortunately, there are still some inconsistencies in products with company pharmacies that they partner with.
  • It\u2019s important to assess what\u2019s going to be effective for you.
[23:24] SS-31
  • SS-31 is a mitochondrial peptide that has market exclusivity.
  • It targets the inner mitochondrial membrane and buffers lipid peroxidation, improving the overall system.
  • Brian and his team are working on enhancing its effects by adding other synergistic materials to it.
[27:33] GHK-Cu
  • GHK-Cu is widely known in the aesthetic space for collagen deposition and reduction of fine lines and wrinkles.
  • Peptides should be used with caution because taking too much might compromise your health.
  • It\u2019s also being used for postoperative recovery and it could potentially help reorient genetic issues and damage.
[31:15] Ta1
  • Thymosin alpha 1 modulates the immune system. It protects immunocompromised people who are more vulnerable to viral bacteria.
  • It\u2019s used for vaccines against viral hepatitis, certain types of cancer, and autoimmune diseases.
  • Essentially, it helps with immunosurveillance by identifying foreign invaders, such as viruses and bacteria, and removing them.
  • Though it has an incredible safety record, it\u2019s under scrutiny and there is limited access to it.
[31:15] Semaglutide and GLP-RA
  • Semaglutide and GLP-RA are synthetic peptides that regulate metabolism, increasing energy utilization and decreasing fat storage.
  • It\u2019s commonly used for glucose control.
  • It also regulates metabolic processes in the brain, potentially reversing cognitive issues.
  • However, it might also lead to nausea, vomiting, distension, and other issues because it slows down stomach emptying.
[43:42] MOD GRF 1-29
  • Overstimulation of CJC-1295, which upregulates growth hormones, can lead to a host of issues, such as fluid retention and neuropathic pain.
  • MOD GRF 1-29 promotes more robust growth hormone production.
  • Using growth hormone-stimulating hormones might cause dependence because it will shut down your ability to produce growth hormones.
  • Abusing growth hormones can shut down your body\u2019s abilities.
  • Growth hormones are released robustly at night and put you in a position to recover.
[49:23] Other Peptides
  • Brian is only familiar with Epithalamin with regards to pineal gland-derived peptides.
  • Cerebral lysine supports the nervous system and can potentially treat Alzheimer\u2019s disease, brain injury, stroke, etc.
  • MOTS-c is a mitochondrial-derived peptide that\u2019s associated with longevity.
  • Humanin is used with MOTS-c, due to its synergistic effects, to encourage greater levels of mitochondria and metabolic flexibility.
  • Metabolic flexibility translates to overall system integrity, resiliency, and performance.
[57:24] Supersapiens
  • Supersapiens sensors track glucose, ketones, and lactate in real-time.
  • It helps enhance your performance and guides you in knowing what you need.
  • It\u2019s best to seek guidance when you start getting into the peptide space so you\u2019ll be able to do things effectively and safely.
7 Powerful Quotes

\u201c... essentially, what it does is it helps to regulate a given process. And that\u2019s what peptides do, they are essentially a key to a door or an opportunity to either lock a door of a given process or open it up\u2026\u201d

\u201c[Peptides] could be analogous to a dimmer switch on the wall: you\u2019re turning up the light or turning down the light, but that\u2019s going to correspond with the given physiologic mechanism.\u201d

\u201cJust because this stuff looks good on paper doesn\u2019t necessarily mean it\u2019s going to be good for everyone. It\u2019s really important to distil down what is going to be effective for you so you\u2019re not wasting your time and your money doing a treatment that you don\u2019t necessarily need.\u201d

\u201cIf you\u2019re in a chronic deteriorative state where your body\u2019s sort of ill-equipped to address that need, then you\u2019re going to chronically upregulate inflammation and essentially chronically deteriorate, unfortunately.\u201d

\u201cMore is not always better.\u201d

\u201cEverything happens in a rhythm. Everything has its own clock.\u201d

\u201cIt\u2019s important [...] to have guidance, whether that\u2019s with me or someone else that is skilled and understands this constantly evolving field to really do things effectively.\u201d

Resources About Brian

Brian Graham is the Program Director at Boulder Longevity Institute. He\u2019s a certified peptide specialist through the International Peptide Society and American Academy for Anti-Aging and Regenerative Medicine.\xa0

Brian is an industrious health and wellness professional with a thorough understanding of clinical peptide modalities. Through his work, he provides high-level concierge health services to patients and is well-versed in peptide sales.\xa0

If you want to know more about Brian, you can connect with him on LinkedIn.\xa0

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To pushing the limits,

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