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Sabestomig in Non-Small Cell Lung Cancer: Bi-Specific Antibody Safe and Active

Published: Nov. 30, 2023, 5:09 p.m.

Patients with non-small cell lung cancer who have failed initial immunotherapy therapy with anti-programmed cell death ligand-1 (PDL-1) checkpoint inhibitors, have responded to a new \u201cbispecific\u201d antibody that targets both the programmed cell death-1 (PD-1) antibody and also the T-cell immunoglobulin and mucin domain 3 (TIM-3) molecule.

\nBenjamin Besse, MD, PhD, Director of Clinical Research at the Department of Cancer Medicine in the Institut Gustave Roussy, Villejuif, Paris, reported a Phase 1/2a study\u2014the first to be done in humans\u2014at the European Society for Medical Oncology 2023 annual congress held in Madrid, Spain. \n

\nOncTimesTalk correspondent, Peter Goodwin, interviewed Besse after the congress to find out about the potential clinical benefits the new drug AZD7789 (now called: sabestomig) among patients whose tumors have the TIM-3 target, and how\u2014together with other targeted approaches\u2014 this bi-specific antibody could impact outcomes for an increasing proportion of patients with lung cancer.