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Professor Serhan expands on the application of SPMs inside the inflammation-resolution cycle and outside this cycle, highlighting alternative mechanisms, the wide scope of SPM therapy and exciting new treatment considerations currently within the field of lipid research.

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• Prof Serhan background on moving into studying lipid mediators. (1:30)
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• Aspirin triggers biosynthesis of lipid mediators. (4:57)
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• Old to new: Review of inflammation and stimulating resolution processes. (6:55)
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• Resolvins reduce neutrophilic infiltration and inducing \u201cself-limitation\u201d. (11:14)
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• Plasticity of macrophage poles \u2013 key function of SPMs. (13:48)
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• Healthy human breast milk contains SPMs. (19:45)
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• Structures, receptors and functional location of Resolvins. (20:44)
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• Downregulation of biosynthetic enzymes and using SPMs. (25:00)
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• Aged mice with enhanced inflammatory response and diminished resolution response. (29:00)
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• SPMs in obesity models. (31:00)
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• Role of SPMs in additional chronic inflammatory conditions. (40:05)
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• SPM killing and clearance of infections without immune suppression. (44:34)
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• SPMs, macrophage types and tumor reduction. (46:45)
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• Topical SPM application in animal models. (49:51)
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• Future publication on periodontal disease. (52:53)
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