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In this episode, my guest is Dr. Peter Attia, M.D., a Stanford and Johns Hopkins School of Medicine-trained physician expert in improving human healthspan and lifespan. Dr. Attia is also the host of The Drive podcast and author of the best-selling book Outlive.\xa0\nWe discuss the NAD pathway in human cells and its possible links to aging and health. We evaluate how supplementation can augment molecules in the NAD pathway; we compare NAD, NMN, and NR, different routes of administration, their safety, and bioavailability. Then, we discuss the broader research and clinical literature on longevity to decide if supplementation with NAD, NR, NMN, rapamycin, or resveratrol can indeed extend lifespan.\xa0\nFinally, we each describe our supplement regimens and compare the role of supplementation to behaviors such as sleep, nutrition, and exercise for longevity. We also discuss whether tests of biological age are true indicators of aging and whether normal radiation levels increase cancer risk.\xa0\nListeners of this episode will learn if supplements purported to improve lifespan show any efficacy and the behaviors and other factors that can prevent disease and extend lifespan.\nAccess the full show notes for this episode at hubermanlab.com.\nThank you to our sponsors\nAG1: https://drinkag1.com/huberman \nLMNT: https://drinklmnt.com/huberman \nLevels: https://levels.link/huberman \nEight Sleep: https://eightsleep.com/huberman \nTimestamps\n00:00:00 Dr. Peter Attia, NAD Pathway\n00:02:31 Sponsors: LMNT, Levels & Eight Sleep\n00:06:38 Categories of Longevity Approaches\n00:17:22 Peter\u2019s Supplements; Rapamycin & Research Data\n00:25:01 NAD Pathway: Energy & DNA Repair; Knock-Out & Knock-In, Klotho\n00:30:35 Sponsor: AG1\n00:32:25 Yeast, Sirtuins, Caloric Restriction & Lifespan\n00:38:56 Sirtuins, Transgenic Mice, Gender & Lifespan\n00:43:42 DNA Repair, Sirtuins, Cancer; Resveratrol\n00:53:31 Perform with Dr. Andy Galpin Podcast\n00:54:18 NAD & NADH, Reactive Oxygen Species (ROS), Mitochondrial Health\n01:02:17 NAD vs NR vs NMN Supplementation; IV & Oral Routes\n01:11:33 NR vs. NMN, Doses, Side Effects; Interventions Testing Program\n01:17:43 Fatty Liver Disease & NR; NMN & Glucose; Clinical Significance\n01:25:17 Safety & FDA, NMN & NR Supplementation; Skin Cancer Benefits\n01:30:38 Longevity, NR & NMN Supplementation, Inflammation\n01:41:00 Rapamycin & Immune Function\n01:44:37 Biological Aging Tests, Chronologic & Biologic Age; Vigor\xa0\n01:55:24 Radiation & Cancer Risk\n01:58:12 Tool: Self-Care in 50s-70s & Aging; Energy Decline\n02:07:12 Tool: Exercise Timing & Energy Levels\n02:11:22 Peter\u2019s Supplements\n02:18:46 Andrew\u2019s Supplements\n02:24:34 Tool: Supplement Use vs. Critical Behaviors; Titanic Analogy\xa0\n02:26:52 NAD Pathway Supplementation for Longevity?\n02:28:52 Zero-Cost Support, YouTube, Spotify & Apple Follow & Reviews, YouTube Feedback, Social Media, Neural Network Newsletter\nDisclaimer