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In this episode, my guest is Dr. Diego Boh\xf3rquez, PhD, professor of medicine and neurobiology at Duke University and a pioneering researcher into how we use our \u2018gut sense.\u2019 He describes how your gut communicates to your brain and the rest of your body through hormones and neural connections to shape your thoughts, emotions, and behaviors. He explains how your gut senses a range of features such as temperature, pH, the macro- and micronutrients in our foods, and much more and signals that information to the brain to affect our food preferences, aversions, and cravings.\nDr. Boh\xf3rquez describes his early life in the Amazon jungle and how exposure to traditional agriculture inspired his unique expertise combining nutrition, gastrointestinal physiology, and neuroscience. We discuss how the gut and brain integrate sensory cues, leading to our intuitive \u201cgut sense\u201d about food, people, and situations. This episode provides a scientific perspective into your gut sense to help you make better food choices and, indeed, to support better decision-making in all of life.\nFor show notes, including referenced articles and additional resources, please visit hubermanlab.com.\nThank you to our sponsors\nAG1: https://drinkag1.com/huberman\nJoovv: https://joovv.com/huberman\nLMNT: https://drinklmnt.com/huberman\nHelix Sleep: https://helixsleep.com/huberman\nInsideTracker: https://insidetracker.com/huberman\nTimestamps\n00:00:00 Dr. Diego Boh\xf3rquez\n00:02:37 Sponsors: Joovv, LMNT & Helix Sleep; YouTube, Spotify & Apple Subscribe\n00:06:49 Gut-Brain Axis\n00:11:35 Gut Sensing, Hormones\n00:15:26 Green Fluorescent Protein; Neuropod Cells & Environment Sensing\n00:26:57 Brain & Gut Connection, Experimental Tools & Rabies Virus\n00:35:28 Sponsor: AG1\n00:37:00 Neuropod Cells & Nutrient Sensing\n00:43:55 Gastric Bypass Surgery, Cravings & Food Choice\n00:51:14 Optogenetics; Sugar Preference & Neuropod Cells\n01:00:29 Gut-Brain Disorders, Irritable Bowel Syndrome\n01:03:03 Sponsor: InsideTracker\n01:04:04 Gut & Behavior; Gastric Bypass, Cravings & Alcohol\n01:07:38 GLP-1, Ozempic, Neuropod Cells\n01:11:46 Food Preference & Gut-Brain Axis, Protein\n01:21:35 Protein & Sugar, Agriculture & \u2018Three Sisters\u2019\n01:25:16 Childhood, Military School; Academics, Nutrition & Nervous System\n01:36:15 Plant Wisdom, Agriculture, Indigenous People\n01:41:48 Evolution of Food Choices; Learning from Plants\n01:48:15 Plant-Based Medicines; Amazonia, Guayusa Ritual & Chonta Palm\n01:56:58 Yerba Mate, Chocolate, Guayusa\n02:00:22 Brain, Gut & Sensory Integration; Variability\n02:06:01 Electrical Patterns in Gut & Brain, \u201cHangry\u201d\n02:12:43 Gut Intuition, Food & Bonding; Subconscious & Superstition\n02:22:00 Vagus Nerve & Learning, Humming\n02:26:46 Digestive System & Memory; Body Sensing\n02:32:51 Listening to the Body, Meditation\n02:40:12 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Social Media, Neural Network Newsletter\nDisclaimer