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\u201cDiet and exercise\u201d has been the weight-loss mantra for decades but a drug designed for diabetes patients could now offer hope to people who are obese, at a time when researchers are warning that half of the world\u2019s population are expected to be overweight or obese by 2035. One of the first to have injections of Semaglutide in the UK was Jan, who has battled with her weight since childhood. Once the medication took effect she lost four stone and said her hunger disappeared.

Professor Stephen O\u2019Rahilly from the University of Cambridge, explains how the drug mimics our body\u2019s natural appetite signalling but its effects disappear once you stop the weekly injections. Family doctor Margaret McCartney says it might help some who are obese but warns that it has also gained a reputation as a \u201cHollywood skinny drug", reflecting some of society\u2019s ideas about beauty and celebrity culture.

Presenter: Claudia Hammond\nProducer: Paula McGrath

(Photo: A jogger running around Clifton Downs, Bristol. Credit: Ben Birchall/PA)