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Psychedelic researcher Dr. Matthew Johnson from Johns Hopkins University joins Dr. Mike Hart to delve deep into the world of psychedelics. Their discussion extends from the therapeutic potential of psychedelic substances in treating mental health disorders such as depression, PTSD, and addiction, to the controversy surrounding their use. Dr. Johnson shares his experiences in pioneering psychedelic research, the therapeutic model he's developing, and insights into the microdosing and macrodosing of substances. They touch upon the societal impact of alcohol and drug misuse, the power of the placebo effect, and how psychedelics interact with traditional treatments like SSRIs. The episode concludes with a nuanced look at the challenges and future direction of the psychedelic space.