Pyrrole Disorder has gained some notoriety in integrative medicine because it's often uncovered via screening of patients with mood or "disorders of socialisation" - particularly in children. The clinical presentation of\xa0Pyrrole\xa0Disorder has a close relationship with methylation and Dr Mark Donohoe articulates this relationship with poise. His overwhelming take-home message\xa0is that we cannot simply take a reductionist approach when treating those who present with pyroluria by\xa0boosting them up with the\xa0required nutrients\xa0but that we must look at the bigger picture and take a broader approach in the healing journey of these patients.